Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
about
Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network.The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partnersComparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxiaThe double-histone-acetyltransferase complex ATAC is essential for mammalian developmentThe structural plasticity of SCA7 domains defines their differential nucleosome-binding propertiesThe transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repairEpigenetic principles and mechanisms underlying nervous system functions in health and diseasePML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteinsGlutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.Transcriptional activators in yeastMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity.Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes.Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export.A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryosPoly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating ModuleDirect inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7.Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disordersThe SAGA continues: expanding the cellular role of a transcriptional co-activator complex.CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.Identification of a small TAF complex and its role in the assembly of TAF-containing complexes.CAG-encoded polyglutamine length polymorphism in the human genomeMolecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegenerationDesign of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype.Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionThe tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elementsExpanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model.Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.Requirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons.Allele-specific silencing of mutant Ataxin-7 in SCA7 patient-derived fibroblasts.Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7.Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy.
P2860
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P2860
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@ast
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en-gb
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@nl
type
label
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@ast
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en-gb
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@nl
prefLabel
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@ast
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en-gb
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@nl
P2093
P50
P356
P1476
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
@en
P2093
Alain Van-Dorsselaer
Chantal Weber
Flavie Robert
Laurent Miguet
Noëlle Potier
Sara Hardy
Souphatta Sasorith
P304
P356
10.1093/HMG/DDH139
P407
P577
2004-04-28T00:00:00Z