Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
about
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activationRestricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathwaysSTIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levelsA novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cellsThe kinase Syk as an adaptor controlling sustained calcium signalling and B-cell developmentHuman muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel componentsSTIM proteins: dynamic calcium signal transducersSTIM1 heteromultimerizes TRPC channels to determine their function as store-operated channelsIP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine programCoupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.An EF hand mutation in Stim1 causes premature platelet activation and bleeding in miceSTIM and Orai1 Variants in Store-Operated Calcium EntryThe role of STIM and ORAI proteins in phagocytic immune cellsSOCE and cancer: Recent progress and new perspectivesMolecular identification of the CRAC channel by altered ion selectivity in a mutant of OraiPhospholipase C signaling and calcium influxPermeation, selectivity and gating in store-operated CRAC channelsOrai3--the 'exceptional' Orai?Molecular regulation of CRAC channels and their role in lymphocyte functionStore-operated Orai channels: structure and functionMultifaceted roles of STIM proteinsNanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entrySTIM1 gates TRPC channels, but not Orai1, by electrostatic interactionMapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activationSTIM1 gates the store-operated calcium channel ORAI1 in vitroAn essential and NSF independent role for α-SNAP in store-operated calcium entryStromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kineticsCritical role for the beta regulatory subunits of Cav channels in T lymphocyte function.Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) miceCPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletionStanniocalcin 2 is a negative modulator of store-operated calcium entryPhospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cellsNative STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neuronsTransient receptor potential melastatin 4 channel controls calcium signals and dental follicle stem cell differentiationNFκB-sensitive Orai1 expression in the regulation of FGF23 release.Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators.Some assembly required: constructing the elementary units of store-operated Ca2+ entry.Novel role for STIM1 as a trigger for calcium influx factor production.
P2860
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P2860
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@ast
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en-gb
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@nl
type
label
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@ast
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en-gb
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@nl
prefLabel
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@ast
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en-gb
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@nl
P2093
P2860
P50
P356
P1433
P1476
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
@en
P2093
Andreas Beck
Annette Lis
Dana L Koomoa
Jean-Pierre Kinet
Monica J S Nadler
Murielle Koblan-Huberson
P2860
P2888
P304
P356
10.1038/NCB1435
P407
P577
2006-05-30T00:00:00Z
P5875
P6179
1028817137