The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase.
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Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein.Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in DrosophilaE3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6HECT E3s and human disease.Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancerHPV E6, E6AP and cervical cancer.miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζRegulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndromeGrowth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformationCidofovir selectivity is based on the different response of normal and cancer cells to DNA damage.A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cellsKnock down of p53 or its ubiquitin ligase E6AP does not affect the sensitivity of human papillomavirus-positive cervical cancer cells to cisplatin.Generation of affibody molecules specific for HPV16 E7 recognitionIdentification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Identification of potential biomarkers from microarray experiments using multiple criteria optimizationNFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6.Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes.HPV E6 protein interacts physically and functionally with the cellular telomerase complex.Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.Emerging topics in human tumor virology.The role of ubiquitin and ubiquitin-like modification systems in papillomavirus biology.High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression.Telomerase Induction in HPV Infection and Oncogenesis.HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function.HPV E6 degradation of p53 and PDZ containing substrates in an E6AP null background.HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP.HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytes.Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression.RNASeq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus type 16 infection, including loss of epithelial barrier function.Cell-restricted immortalization by human papillomavirus correlates with telomerase activation and engagement of the hTERT promoter by Myc.The regulation of telomerase in oncogenesis.Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD.Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation.Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β
P2860
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P2860
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The global transcriptional eff ...... d by the E6AP ubiquitin ligase
@nl
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@ast
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en-gb
type
label
The global transcriptional eff ...... d by the E6AP ubiquitin ligase
@nl
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@ast
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en-gb
prefLabel
The global transcriptional eff ...... d by the E6AP ubiquitin ligase
@nl
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@ast
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en-gb
P2093
P2860
P3181
P1433
P1476
The global transcriptional eff ...... by the E6AP ubiquitin ligase.
@en
P2093
Chan Jae Lee
Jon M Huibregtse
Kerri E Keiger
Melissa L Kelley
P2860
P304
P3181
P356
10.1128/JVI.79.6.3737-3747.2005
P407
P577
2005-03-01T00:00:00Z