The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma - Test2 - elhamkhani - TriplyDB

The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

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Epigenetic field defects in progression to cancer Reactive oxygen species: role in the development of cancer and various chronic conditions Mycotoxins and human disease: a largely ignored global health issue Targeting DNA Damage Response in the Radio(Chemo)therapy of Non-Small Cell Lung Cancer Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species Structural Perturbations Induced by the α-Anomer of the Aflatoxin B 1 Formamidopyrimidine Adduct in Duplex and Single-Strand DNA Bypass of Aflatoxin B 1 Adducts by the Sulfolobus solfataricus DNA Polymerase IV Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249 Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts.Biological properties of single chemical-DNA adducts: a twenty year perspective Molecular genetics of hepatocellular neoplasia.Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.Error-prone replication bypass of the primary aflatoxin B1 DNA adduct, AFB1-N7-Gua Aflatoxin B(1)-Associated DNA Adducts Stall S Phase and Stimulate Rad51 foci in Saccharomyces cerevisiae Aflatoxin B1 up-regulates insulin receptor substrate 2 and stimulates hepatoma cell migration A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation.Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.The formation and biological significance of N7-guanine adducts An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.DNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 Adduct Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.Hep88 mAb-initiated paraptosis-like PCD pathway in hepatocellular carcinoma cell line through the binding of mortalin (HSPA9) and alpha-enolase.Chemical reaction of soybean flavonoids with DNA: a computational study using the implicit solvent model.Codon 249 mutation in exon 7 of p53 gene in plasma DNA: maybe a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China.Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews.Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver.Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress.Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.Specific mutations of hepatitis B virus in plasma predict liver cancer development.Stimulation of sister chromatid exchanges and mutation by aflatoxin B1-DNA adducts in Saccharomyces cerevisiae requires MEC1 (ATR), RAD53, and DUN1 In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine.Chemistry and structural biology of DNA damage and biological consequences An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae.

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The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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Proceedings of the National Academy of Sciences of the United States of America

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The aflatoxin B(1) formamidopy ...... human hepatocellular carcinoma

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Constance M Harris

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John M Essigmann

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Maryann E Smela

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Michelle L Hamm

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Paul T Henderson

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Thomas M Harris

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P2860

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily

Refined solution structure of 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the complementary strand of an oligodeoxynucleotide duplex as determined by 1H NMR

An intercalated and thermally stable FAPY adduct of aflatoxin B1 in a DNA duplex: structural refinement from 1H NMR

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

Genetic alterations during colorectal-tumor development

Intrinsic polymerase activities of UmuD'(2)C and MucA'(2)B are responsible for their different mutagenic properties during bypass of a T-T cis-syn cyclobutane dimer.

Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2.

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage tolerance.

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6655-60

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10.1073/PNAS.102167699

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10

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99

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12011430

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