Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.
about
Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness.Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei.Secretory pathway of trypanosomatid parasites.Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei.Glycan antagonists and inhibitors: a fount for drug discovery.Lipid metabolism in Trypanosoma bruceiTrypanosome glycosylphosphatidylinositol biosynthesis.Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery.Drug targets in Leishmania.Chemical biology of glycosylphosphatidylinositol anchors.Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase.Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues.Subcellular localization and targeting of N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, the second enzyme in the glycosylphosphatidylinositol biosynthetic pathway.Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness.N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase from Entamoeba histolytica: metal alters catalytic rates but not substrate affinity.Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in Trypanosoma brucei and HeLa cells.Glycosylphosphatidylinositols synthesized by Trichophyton rubrum in a cell-free system.Identity of cofactor bound to mycothiol conjugate amidase (Mca) influenced by expression and purification conditions.The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme.Targeting the GPI biosynthetic pathway.
P2860
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P2860
Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.
description
2001 nî lūn-bûn
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2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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name
Specificity of GlcNAc-PI de-N- ...... c suicide substrate inhibitors
@nl
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@ast
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@en
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@en-gb
type
label
Specificity of GlcNAc-PI de-N- ...... c suicide substrate inhibitors
@nl
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@ast
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@en
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@en-gb
prefLabel
Specificity of GlcNAc-PI de-N- ...... c suicide substrate inhibitors
@nl
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@ast
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@en
Specificity of GlcNAc-PI de-N- ...... suicide substrate inhibitors.
@en-gb
P2093
P2860
P356
P1433
P1476
Specificity of GlcNAc-PI de-N- ...... c suicide substrate inhibitors
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/20.13.3322
P407
P577
2001-07-01T00:00:00Z