Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development
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Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanismsGlobal transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cellsProtein lysine acetylation by p300/CBPStructural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domainsRas signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBPDistinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivationGenetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repressionNF-Y is essential for expression of the proapoptotic bim gene in sympathetic neuronsT-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organsHistone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype.CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.TLX1/HOX11-induced hematopoietic differentiation blockade.Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopeniaRegulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.Presenilin controls CBP levels in the adult Drosophila central nervous system.Control of B cell development by the histone H2A deubiquitinase MYSM1.CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.Prepaying the entropic cost for allosteric regulation in KIXGraded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation.Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancersTranscriptional control of erythropoiesis: emerging mechanisms and principles.CREBBP mutations in relapsed acute lymphoblastic leukaemia.Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory.Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic controlMicroRNA 132 alters sleep and varies with time in brain.Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and functionIdentification and computational analysis of gene regulatory elements.Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits.Is histone acetylation the most important physiological function for CBP and p300?Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression.Genetic and epigenetic mechanisms of gene regulation during lens development.Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.Live-cell studies of p300/CBP histone acetyltransferase activity and inhibitionRegulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoDp300 is not required for metabolic adaptation to endurance exercise training.Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling
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P2860
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development
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2006 nî lūn-bûn
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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2006 թվականի փետրվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Conditional knockout mice reve ...... and p300 in T-cell development
@ast
Conditional knockout mice reve ...... and p300 in T-cell development
@en
Conditional knockout mice reve ...... and p300 in T-cell development
@nl
type
label
Conditional knockout mice reve ...... and p300 in T-cell development
@ast
Conditional knockout mice reve ...... and p300 in T-cell development
@en
Conditional knockout mice reve ...... and p300 in T-cell development
@nl
prefLabel
Conditional knockout mice reve ...... and p300 in T-cell development
@ast
Conditional knockout mice reve ...... and p300 in T-cell development
@en
Conditional knockout mice reve ...... and p300 in T-cell development
@nl
P2093
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P50
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P1476
Conditional knockout mice reve ...... and p300 in T-cell development
@en
P2093
Antoine de Pauw
Caili Tong
Jan M A van Deursen
Lawryn H Kasper
Michelle A Biesen
Peter J Murray
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P304
P3181
P356
10.1128/MCB.26.3.789-809.2006
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P577
2006-02-01T00:00:00Z