A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation
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Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE studyMutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNAMutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutationsReactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss.Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxesThe human mitochondrial transcriptome and the RNA-binding proteins that regulate its expressionThe universally conserved prokaryotic GTPasesKissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopyMutations in the yeast mrf1 gene encoding mitochondrial release factor inhibit translation on mitochondrial ribosomes.Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coliMaternally inherited aminoglycoside-induced and nonsyndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese familyCombination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration.A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs.Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetesMutations in GTPBP3 cause a mitochondrial translation defect associated with hypertrophic cardiomyopathy, lactic acidosis, and encephalopathytRNA modification enzymes GidA and MnmE: potential role in virulence of bacterial pathogens.Characterization of human GTPBP3, a GTP-binding protein involved in mitochondrial tRNA modification.Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiaeAudio profiles in mitochondrial deafness m.1555A>G and m.3243A>G show distinct differences.Disorders of mitochondrial protein synthesis.Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria.MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutationMitochondrial transcript maturation and its disordersChanges in Mitochondrial Toxicity in Peripheral Blood Mononuclear Cells During Four-Year Administration of Entecavir Monotherapy in Chinese Patients with Chronic Hepatitis BMitochondrial ribosome assembly in health and diseaseExpression and maintenance of mitochondrial DNA: new insights into human disease pathologyAre GJB2 mutations an aggravating factor in the phenotypic expression of mitochondrial non-syndromic deafness?Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease.Invited review: MnmE, a GTPase that drives a complex tRNA modification reaction.Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation.Stabilization of G domain conformations in the tRNA-modifying MnmE-GidA complex observed with double electron electron resonance spectroscopy.The structure of the TrmE GTP-binding protein and its implications for tRNA modification.Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.The tRNA-modifying function of MnmE is controlled by post-hydrolysis steps of its GTPase cycle.Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions.The GTPase activity and C-terminal cysteine of the Escherichia coli MnmE protein are essential for its tRNA modifying function.PharmGKB summary: very important pharmacogene information for MT-RNR1.Towards the Prevention of Aminoglycoside-Related Hearing Loss.Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification.
P2860
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P2860
A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@ast
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@en
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@nl
type
label
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@ast
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@en
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@nl
prefLabel
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@ast
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@en
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@nl
P2860
P1476
A human mitochondrial GTP bind ...... itochondrial 12S rRNA mutation
@en
P2093
Min-Xin Guan
Xiaoming Li
P2860
P304
P356
10.1128/MCB.22.21.7701-7711.2002
P407
P577
2002-11-01T00:00:00Z