Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis
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REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasisThe sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavageCharacterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifsHair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatinOverexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesisTwist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1cSuppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profileCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular EffectsTranscriptional regulation of hepatic lipogenesisDual functions of Insig proteins in cholesterol homeostasisMembrane topology of human insig-1, a protein regulator of lipid synthesisAkt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysAssociation between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseChromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expressionSchoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsDistinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1cGenetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly populationDocosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathwaysInsulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesiclesEffects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens.Insulin and glucose play a role in foam cell formation and function.Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.ER stress and hepatic lipid metabolism.Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP.Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal ratsInhibition of SREBP transcriptional activity by a boron-containing compound improves lipid homeostasis in diet-induced obesityObesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle.Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemiaAdaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesityEndoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potentialActivation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
P2860
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P2860
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@ast
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@en
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@nl
type
label
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@ast
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@en
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@nl
prefLabel
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@ast
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@en
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@nl
P2093
P2860
P3181
P356
P1476
Liver-specific mRNA for Insig- ...... tions for fatty acid synthesis
@en
P2093
Guosheng Liang
Michael S Brown
Ryutaro Komuro
P2860
P304
P3181
P356
10.1073/PNAS.0130116100
P407
P577
2003-03-06T00:00:00Z