Sir2 mediates longevity in the fly through a pathway related to calorie restriction
about
Calories do not explain extension of life span by dietary restriction in DrosophilaSIRT2 as a Therapeutic Target for Age-Related DisordersRecent developments in yeast agingIncreased life span due to calorie restriction in respiratory-deficient yeastJNK1 phosphorylates SIRT1 and promotes its enzymatic activityReversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2Phosphorylation of HuR by Chk2 regulates SIRT1 expressionEvolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteinsSIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXOSirtuins deacetylate and activate mammalian acetyl-CoA synthetasesRapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous miceSIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stressNutrient-sensitive mitochondrial NAD+ levels dictate cell survivalEpigenetic alterations in agingSpatial protein quality control and the evolution of lineage-specific ageingSIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1Biochemical effects of SIRT1 activatorsChromatin regulation and genome maintenance by mammalian SIRT6Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesThe neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodiesResveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanCalorie restriction and the exercise of chromatinSIRT6 in DNA repair, metabolism and ageingIdentification of FOXO targets that generate diverse features of the diapause phenotype in the mosquito Culex pipiensSirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsSynaptic and genomic responses to JNK and AP-1 signaling in Drosophila neuronsSIRT1 and Kidney FunctionFinding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesWine Resveratrol: From the Ground UpSirt1 and the MitochondriaBiochemical Genetic Pathways that Modulate Aging in Multiple SpeciesProtective effects and mechanisms of sirtuins in the nervous systemSirtuin 1 and sirtuin 3: physiological modulators of metabolismSirtuins as regulators of metabolism and healthspanThe controversial world of sirtuinsNitric oxide, oxidative stress, and p66Shc interplay in diabetic endothelial dysfunctionThe benefits of humanized yeast models to study Parkinson's diseaseCommon features of chromatin in aging and cancer: cause or coincidence?
P2860
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P2860
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@ast
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@en
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@nl
type
label
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@ast
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@en
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@nl
prefLabel
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@ast
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@en
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@nl
P2860
P3181
P356
P1476
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
@en
P2093
Stephen L Helfand
P2860
P304
15998-16003
P3181
P356
10.1073/PNAS.0404184101
P407
P577
2004-11-01T00:00:00Z