Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells - Test2 - elhamkhani - TriplyDB

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

http://www.wikidata.org/entity/Q24561962

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Targeting cellular metabolism to improve cancer therapeutics Potential role of tumor necrosis factor-α in downregulating sex hormone-binding globulin Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene Targeting metabolism in breast cancer: How far we can go?The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer Lipid biology of breast cancer The role of HGF/c-MET signaling pathway in lymphoma Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma Lipid metabolism emerges as a promising target for malignant glioma therapy.Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.Pathogenesis of ovarian cancer: clues from selected overexpressed genes.The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression.HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.Association of lipid metabolism with ovarian cancer Fatty acid synthase inhibition by amentoflavone suppresses HER2/neu (erbB2) oncogene in SKBR3 human breast cancer cells.Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity.De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro.Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer.Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice.Plasma metabolite profiling and chemometric analyses of lung cancer along with three controls through gas chromatography-mass spectrometry.Signalling mechanisms regulating phenotypic changes in breast cancer cells.Fatty acid synthase as a potential therapeutic target in cancer.Metformin: multi-faceted protection against cancer.ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.Multiplexing siRNAs to compress RNAi-based screen size in human cells.A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.Interfering with cancer: a brief outline of advances in RNA interference in oncology.Palmitate-induced ER stress increases trastuzumab sensitivity in HER2/neu-positive breast cancer cells Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways Potential applications of RNA interference technology in the treatment of cancer.ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells.Potential use of humanized antibodies in the treatment of breast cancer.

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Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

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2004年の論文

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inhibition of fatty acid synth ...... overexpression in cancer cells

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Inderjit Mehmi

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Luciano Vellon

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Ruth Lupu

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Santiago Ropero

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P2860

Humanization of an anti-p185HER2 antibody for human cancer therapy

Fatty acid synthesis: a potential selective target for antineoplastic therapy

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

Expression of haptoglobin-related protein and its potential role as a tumor antigen

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology.

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

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