ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
about
betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous systemDephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretionThe neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretionNuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cellsSynthesis and secretion of renin in mice with induced genetic mutationsThe F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granulesT-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agentsStructural genomics of protein phosphatasesICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATsThe diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretionSelf-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organsDisturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesiclesRegulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.Secretory granule membrane protein recycles through multivesicular bodiesA novel CaM kinase II pathway controls the location of neuropeptide release from Caenorhabditis elegans motor neurons.Distinct clinical and laboratory characteristics of latent autoimmune diabetes in adults in relation to type 1 and type 2 diabetes mellitus.Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases.Misfolded proinsulin affects bystander proinsulin in neonatal diabetesThe dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.The pancreas in human type 1 diabetes.B cells in autoimmune diabetesCyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.Islet autoantigens: structure, function, localization, and regulation.Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease.Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate diseaseDisruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2βIA-2 modulates dopamine secretion in PC12 cells.The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes.Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brainNon-antigenic and antigenic interventions in type 1 diabetesDense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growthSmall cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.
P2860
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P2860
ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@ast
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@en
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@nl
type
label
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@ast
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@en
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@nl
prefLabel
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@ast
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@en
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@nl
P2093
P2860
P3181
P1433
P1476
ICA 512, an autoantigen of typ ...... ein of neurosecretory granules
@en
P2093
J A Shapiro
M Solimena
S Pleasic-Williams
P2860
P304
P3181
P356
10.1002/J.1460-2075.1996.TB00564.X
P407
P577
1996-05-01T00:00:00Z