Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
about
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in miceAtherosclerosisThe organization and consequences of eicosanoid signalingChronic Inflammatory Diseases and Endothelial DysfunctionThe role of lipoxygenases in pathophysiology; new insights and future perspectivesDietary polyunsaturated fatty acids and inflammation: the role of phospholipid biosynthesisThe SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDLReactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell FormationOpportunities for the treatment of inflammation in cardiovascular diseaseExpanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesisMammalian lipoxygenases and their biological relevanceBiosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidVascular biology of eicosanoids and atherogenesisFunctional and pathological roles of the 12- and 15-lipoxygenasesPolyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages.Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migrationEffects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAsRegulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptorsNitric oxide is a physiological substrate for mammalian peroxidasesHuman Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating EicosanoidIncreased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice.12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injuryNonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetesImproved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease.Oxidative risk for atherothrombotic cardiovascular disease.Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro.Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression.Peroxisome proliferator-activated receptors in the cardiovascular system.AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis.Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells.StAR overexpression decreases serum and tissue lipids in apolipoprotein E-deficient mice.Potential role of oxidized lipids and lipoproteins in antioxidant defense.Genetic modifiers of atherosclerosis in micePotential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins.15-lipoxygenase-1: a prooxidant enzyme.
P2860
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P2860
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@ast
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@en
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@nl
type
label
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@ast
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@en
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@nl
prefLabel
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@ast
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@en
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@nl
P2093
P2860
P3181
P356
P1476
Disruption of the 12/15-lipoxy ...... erosis in apo E-deficient mice
@en
P2093
J L Witztum
M F Linton
R Tangirala
P2860
P304
P3181
P356
10.1172/JCI5897
P407
P577
1999-06-01T00:00:00Z