Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
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Roles of bioactive sphingolipids in cancer biology and therapeuticsThe emerging role of FTY720 (Fingolimod) in cancer treatmentBlockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularizationTranscription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.Characterization of a sphingosine 1-phosphate receptor antagonist prodrugS1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.Host endothelial S1PR1 regulation of vascular permeability modulates tumor growthIdentification of the hydrophobic ligand binding pocket of the S1P1 receptorAn autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival.Twofer anti-vascular therapy targeting sphingosine-1-phosphate for breast cancer.Re-configuration of sphingolipid metabolism by oncogenic transformation.GPCRs and cancerS1P metabolism in cancer and other pathological conditions.Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules.Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degenerationConnective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.Roles of sphingosine 1-phosphate on tumorigenesisSTAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.Sphingosine-1-phosphate receptor 2Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind HydeEmerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.Effects of lysophospholipids on tumor microenvironmentA novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina.Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer.S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.Flow-regulated endothelial S1P receptor-1 signaling sustains vascular developmentThe role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence.Pathophysiology of tumor neovascularization.Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis.Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170.The vascular S1P gradient-cellular sources and biological significance.Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature.Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.
P2860
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P2860
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@ast
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@en
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@nl
type
label
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@ast
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@en
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@nl
prefLabel
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@ast
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@en
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@nl
P2860
P356
P1476
Requirement for sphingosine 1- ...... ed by in vivo RNA interference
@en
P2093
Ji-Hye Paik
Sung-Suk Chae
P2860
P304
P356
10.1172/JCI22716
P407
P577
2004-10-01T00:00:00Z