Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests - Test2 - elhamkhani - TriplyDB

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

http://www.wikidata.org/entity/Q24564195

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Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice.A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus Synthesis of galmic: a nonpeptide galanin receptor agonist Galanin in Alzheimer's disease: neuroinhibitory or neuroprotective?Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests Regulators of synaptic transmission: roles in the pathogenesis and treatment of epilepsy Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2).Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze.Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms.GAL3 receptor KO mice exhibit an anxiety-like phenotype.A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats.The galanin-R2 agonist AR-M1896 reduces glutamate toxicity in primary neural hippocampal cells.Neuropeptide receptor positive allosteric modulation in epilepsy: galanin modulation revealed.GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models.In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures.Alteration of behavioral changes and hippocampus galanin expression in chronic unpredictable mild stress-induced depression rats and effect of electroacupuncture treatment Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response.Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055 Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2.Homology modeling, docking, and molecular dynamics simulation of the receptor GALR2 and its interactions with galanin and a positive allosteric modulator.Galanin and cognition.Galanin receptors and ligands.Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease.Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma.Neuroprotective role for galanin in Alzheimer's disease.Anticonvulsant neuropeptides as drug leads for neurological diseases.Ghrelin: an emerging new anticonvulsant neuropeptide.Galanin receptors as a potential target for neurological disease.Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.On the existence and function of galanin receptor heteromers in the central nervous system Oleuropein attenuates visceral adiposity in high-fat diet-induced obese mice through the modulation of WNT10b- and galanin-mediated signalings.Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system.Plasma galanin is a biomarker for severity of major depressive disorder.Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit.GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors.Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.

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P2860

Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests

http://www.wikidata.org/entity/Q24564195

description

2004 nî lūn-bûn

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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2004 թվականի հուլիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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Galmic, a nonpeptide galanin r ...... e, pain, and forced-swim tests

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Galmic, a nonpeptide galanin r ...... e, pain, and forced-swim tests

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Galmic, a nonpeptide galanin r ...... e, pain, and forced-swim tests

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Galmic, a nonpeptide galanin r ...... e, pain, and forced-swim tests

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Proceedings of the National Academy of Sciences of the United States of America

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Galmic, a nonpeptide galanin r ...... e, pain, and forced-swim tests

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Alasdair M Barr

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Andrey Mazarati

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Gebhard Haberhauer

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Hedieh Badie-Mahdavi

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Laszlo Somogyi

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Laurent Trembleau

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Lenz Kröck

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Susana Conde Ceide

http://www.w3.org/2001/XMLSchema#string

Tony Yaksh

http://www.w3.org/2001/XMLSchema#string

Xiao-Ying Hua

http://www.w3.org/2001/XMLSchema#string

P2860

Anticonvulsant activity of a nonpeptide galanin receptor agonist.

Galanin receptor subtypes

Galanin: a biologically active peptide

Is the forced swimming test a suitable model for revealing antidepressant activity?

Synthesis of a second-generation pseudopeptide platform

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

Somatostatin analogs.

Galanin: an endogenous anticonvulsant?

The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal.

Neuropeptides: opportunities for drug discovery.

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