Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts
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Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organizationDual function of TGFβ in lens epithelial cell fate: implications for secondary cataract.Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposureTemporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation.Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-CTgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK.Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic miceActivation of unfolded protein response in transgenic mouse lenses.Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.Quantitative analysis of injury-induced anterior subcapsular cataract in the mouse: a model of lens epithelial cells proliferation and epithelial-mesenchymal transitionQuantitative relationships between transforming growth factor beta mRNA isoforms in congenital and traumatic cataractsTGFbeta induces morphological and molecular changes similar to human anterior subcapsular cataractEnhanced expression of transglutaminase 2 in anterior polar cataracts and its induction by TGF-beta in vitroAn essential role for FGF receptor signaling in lens developmentConditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract.Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.Anterior segment dysgenesis after overexpression of transforming growth factor-beta-induced gene, beta igh3, in the mouse eye.Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells.Cell cycle regulation in the developing lens.Altered expression of transforming growth factor beta 1 and matrix metalloproteinase-9 results in elevated intraocular pressure in miceMatrix Metalloproteinases as Mediators of Primary and Secondary CataractsAdenoviral gene transfer of bioactive TGFbeta1 to the rodent eye as a novel model for anterior subcapsular cataractGlutathione and catalase suppress TGFbeta-induced cataract-related changes in cultured rat lenses and lens epithelial explantsTGFbeta promotes Wnt expression during cataract developmentIntegrins in lens development and disease.Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse.β-Catenin/CBP-Dependent Signaling Regulates TGF-β-Induced Epithelial to Mesenchymal Transition of Lens Epithelial CellsThe epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells.FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.The murine lens: A model to investigate in vivo epithelial-mesenchymal transition.Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues.IGF-1 counteracts TGF-beta-mediated enhancement of fibronectin for in vitro human lens epithelial cells.Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium.Matrix metalloproteinase-9-null mice are resistant to TGF-β-induced anterior subcapsular cataract formation.Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells.Induction of corneal myofibroblasts by lens-derived transforming growth factor beta1 (TGFbeta1): a transgenic mouse model.alpha-Smooth muscle actin is constitutively expressed in the lens epithelial cells of several species.Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival
P2860
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P2860
Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Lens-specific expression of tr ...... anterior subcapsular cataracts
@ast
Lens-specific expression of tr ...... anterior subcapsular cataracts
@en
Lens-specific expression of tr ...... anterior subcapsular cataracts
@nl
type
label
Lens-specific expression of tr ...... anterior subcapsular cataracts
@ast
Lens-specific expression of tr ...... anterior subcapsular cataracts
@en
Lens-specific expression of tr ...... anterior subcapsular cataracts
@nl
prefLabel
Lens-specific expression of tr ...... anterior subcapsular cataracts
@ast
Lens-specific expression of tr ...... anterior subcapsular cataracts
@en
Lens-specific expression of tr ...... anterior subcapsular cataracts
@nl
P2860
P3181
P356
P1476
Lens-specific expression of tr ...... anterior subcapsular cataracts
@en
P2093
F J Lovicu
Y Srinivasan
P2860
P304
P3181
P356
10.1172/JCI1360
P407
P577
1998-02-01T00:00:00Z