Adhesion signaling by a novel mitotic substrate of src kinases - Test2 - elhamkhani - TriplyDB

Adhesion signaling by a novel mitotic substrate of src kinases

Adhesion signaling by a novel mitotic substrate of src kinases

http://www.wikidata.org/entity/Q24594187

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The structural features of Trask that mediate its anti-adhesive functions The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival Novel surface targets and serum biomarkers from the ovarian cancer vasculature Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1.Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries Diversity of matriptase expression level and function in breast cancer.CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production.Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers.Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia.CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis.Structural requirements for cub domain containing protein 1 (CDCP1) and Src dependent cell transformation VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination.Matriptase: potent proteolysis on the cell surface.Trask phosphorylation defines the reverse mode of a phosphotyrosine signaling switch that underlies cell anchorage state Targeting tumor cell motility to prevent metastasis.Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.A tumor-suppressing function in the epithelial adhesion protein Trask.CUB domain containing protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells.Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734 Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors.Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype.Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.CD318/CUB-domain-containing protein 1 expression on cord blood hematopoietic progenitors.Interdependence of cell attachment and cell cycle signaling.Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer

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P2860

Adhesion signaling by a novel mitotic substrate of src kinases

http://www.wikidata.org/entity/Q24594187

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

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2005年論文

@zh-tw

2005年论文

@wuu

name

Adhesion signaling by a novel mitotic substrate of src kinases

@ast

Adhesion signaling by a novel mitotic substrate of src kinases

@en

Adhesion signaling by a novel mitotic substrate of src kinases

@nl

type

label

Adhesion signaling by a novel mitotic substrate of src kinases

@ast

Adhesion signaling by a novel mitotic substrate of src kinases

@en

Adhesion signaling by a novel mitotic substrate of src kinases

@nl

prefLabel

Adhesion signaling by a novel mitotic substrate of src kinases

@ast

Adhesion signaling by a novel mitotic substrate of src kinases

@en

Adhesion signaling by a novel mitotic substrate of src kinases

@nl

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Adhesion signaling by a novel mitotic substrate of src kinases

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Ami S Bhatt

http://www.w3.org/2001/XMLSchema#string

Charles S Craik

http://www.w3.org/2001/XMLSchema#string

Mark M Moasser

http://www.w3.org/2001/XMLSchema#string

P2860

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

Functional interaction between c-Src and its mitotic target, Sam 68

pp60c-src activation in human colon carcinoma

Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease

Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha

Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy

A target for Src in mitosis.

An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis.

Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.

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5333-43

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scholarly article

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4111077

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10.1038/SJ.ONC.1208582

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34

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24

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Hediye Erdjument-Bromage

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2005-08-11T00:00:00Z

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7737774

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1003173700

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16007225

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3023961

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