U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction
about
Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingIdentification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosomeThe N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA bindingConservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plantsBiochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiaeMultiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangementsEvidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAsA novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionPRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitroPseudouridines in spliceosomal snRNAsCooperative structure of the heterotrimeric pre-mRNA retention and splicing complexMolecular architecture of the Saccharomyces cerevisiae activated spliceosomeA U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae.Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicingProgression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociationPrp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP.Pre-mRNA splicing within an assembled yeast spliceosome requires an RNA-dependent ATPase and ATP hydrolysisThe DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.Functional association of essential splicing factor(s) with PRP19 in a protein complex.The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing systemA composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.Computational identification of four spliceosomal snRNAs from the deep-branching eukaryote Giardia intestinalis.Site-specific deoxynucleotide substitutions in yeast U6 snRNA block splicing of pre-mRNA in vitro.The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling.Genetic interactions of conserved regions in the DEAD-box protein Prp28p.The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle.Formation of the yeast splicing complex A1 and association of the splicing factor PRP19 with the pre-mRNA are independent of the 3' region of the intron.The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes.The abundance of the spliceosomal snRNPs is not limiting the splicing of U12-type introns.Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.The spliceosome: a flexible, reversible macromolecular machine.A base-pairing interaction between U2 and U6 small nuclear RNAs occurs in > 150S complexes in HeLa cell extracts: implications for the spliceosome assembly pathway.Mutational analysis of Saccharomyces cerevisiae U4 small nuclear RNA identifies functionally important domains.PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels.Free energy landscapes of RNA/RNA complexes: with applications to snRNA complexes in spliceosomes.
P2860
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P2860
U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction
description
1991 nî lūn-bûn
@nan
1991 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@ast
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@en
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@nl
type
label
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@ast
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@en
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@nl
prefLabel
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@ast
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@en
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@nl
P2860
P3181
P356
P1476
U4 small nuclear RNA dissociat ...... e subsequent splicing reaction
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.11.11.5571
P407
P577
1991-11-01T00:00:00Z