Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

Item
http://www.wikidata.org/entity/Q24597322
VNI cures acute and chronic experimental Chagas diseaseComplexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITYA convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditionsEnantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes.VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.Cellular response to Trypanosoma cruzi infection induces secretion of defensin α-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection.Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.Enantioselective methodologies using N-carbamoyl-imines.Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors.
P2860

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

Item
http://www.wikidata.org/entity/Q24597322
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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Organocatalytic, enantioselect ...... , a neglected tropical disease
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P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932