Intramolecular interactions regulate SAP97 binding to GKAP
about
A post-synaptic scaffold at the origin of the animal kingdomDifferent isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cellsCraniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large genep38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAPCytoskeleton Molecular Motors: Structures and Their Functions in NeuronStructural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domainsInsights into Regulated Ligand Binding Sites from the Structure of ZO-1 Src Homology 3-Guanylate Kinase ModuleThe Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor traffickingLigand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channelMolecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97Evidence for two concentration-dependent processes for beta-subunit effects on alpha1B calcium channelsOncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressorClustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.Subunit-specific regulation of N-methyl-D-aspartate (NMDA) receptor trafficking by SAP102 protein splice variantsSupertertiary structure of the synaptic MAGuK scaffold proteins is conservedPhosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic density-95 (PSD-95) protein, a membrane-associated guanylate kinase (MAGUK).Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) actiAllosteric control of regulated scaffolding in membrane-associated guanylate kinasesIntramolecular interactions between the SRC homology 3 and guanylate kinase domains of discs large regulate its function in asymmetric cell divisionThe effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties.Structural modeling of protein interactions by analogy: application to PSD-95Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder.Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.Protein 4.1-mediated membrane targeting of human discs large in epithelial cells.Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region.The SH3, HOOK and guanylate kinase-like domains of hDLG are important for its cytoplasmic localization.Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity.Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriersA functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization.Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells.Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity.MAGUKs end a tale of promiscuity.PALS1 regulates E-cadherin trafficking in mammalian epithelial cellsIntramolecular ex vivo Fluorescence Resonance Energy Transfer (FRET) of Dihydropyridine Receptor (DHPR) β1a Subunit Reveals Conformational Change Induced by RYR1 in Mouse Skeletal MyotubesThe molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorsCharacterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function.
P2860
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P2860
Intramolecular interactions regulate SAP97 binding to GKAP
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Intramolecular interactions regulate SAP97 binding to GKAP
@ast
Intramolecular interactions regulate SAP97 binding to GKAP
@en
Intramolecular interactions regulate SAP97 binding to GKAP
@nl
type
label
Intramolecular interactions regulate SAP97 binding to GKAP
@ast
Intramolecular interactions regulate SAP97 binding to GKAP
@en
Intramolecular interactions regulate SAP97 binding to GKAP
@nl
prefLabel
Intramolecular interactions regulate SAP97 binding to GKAP
@ast
Intramolecular interactions regulate SAP97 binding to GKAP
@en
Intramolecular interactions regulate SAP97 binding to GKAP
@nl
P2093
P2860
P3181
P356
P1433
P1476
Intramolecular interactions regulate SAP97 binding to GKAP
@en
P2093
B Coblentz
C C Garner
C Reissner
S Kuhlendahl
P2860
P304
P3181
P356
10.1093/EMBOJ/19.21.5740
P407
P577
2000-11-01T00:00:00Z