HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis - Test2 - elhamkhani - TriplyDB

HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

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Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer Is red cell distribution width a novel biomarker of breast cancer activity? Data from a pilot study.The impact of human adipose tissue-derived stem cells on breast cancer cells: implications for cell-assisted lipotransfers in breast reconstruction.HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer Microenvironment, oncoantigens, and antitumor vaccination: lessons learned from BALB-neuT mice.Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications.Current Approaches and Emerging Directions in HER2-resistant Breast Cancer.Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells.Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia Noncoding RNAs that associate with YB-1 alter proliferation in prostate cancer cells.Elevated PI3K signaling drives multiple breast cancer subtypes.Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers.Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.Targeting of Rac GTPases blocks the spread of intact human breast cancer.STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer.Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer.MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients.Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6.Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.Trastuzumab-Resistant Luminal B Breast Cancer Cells Show Basal-Like Cell Growth Features Through NF-κB-Activation Constitutive activation of STAT3 in breast cancer cells: A review.Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits.Interleukin-6 expression contributes to lapatinib resistance through maintenance of stemness property in HER2-positive breast cancer cells.Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells.Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts.Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people.PI3K and STAT3: a new alliance.Tumor dormancy and the neuroendocrine system: an undisclosed connection?lnflammation-induced epigenetic switches in cancer.Gene Expression Meta-Analysis of Potential Metastatic Breast Cancer Markers.Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities

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HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

http://www.wikidata.org/entity/Q24598092

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2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011年の論文

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Cancer Research

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HER2 overexpression elicits a ...... is critical for tumorigenesis

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Gangjun Lei

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Michael A Morse

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Oliver Glass

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Sandeep S Dave

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P2860

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

STATs in cancer inflammation and immunity: a leading role for STAT3

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

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4380-4391

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10.1158/0008-5472.CAN-11-0308

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13

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71

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Herbert Kim Lyerly

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2011-04-25T00:00:00Z

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21518778

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3129398

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