Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma - Test2 - elhamkhani - TriplyDB

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma

http://www.wikidata.org/entity/Q24599833

about

Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds Discovery and resupply of pharmacologically active plant-derived natural products: A review Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma Honokiol: a non-adipogenic PPARγ agonist from nature Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders Drugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network project Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligands Identification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validation Identification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activity Accessing biological actions of Ganoderma secondary metabolites by in silico profiling Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.Identification of novel liver X receptor activators by structure-based modeling Magnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance.Glycolytic switch in response to betulinic acid in non-cancer cells Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.n-Hexane Insoluble Fraction of Plantago lanceolata Exerts Anti-Inflammatory Activity in Mice by Inhibiting Cyclooxygenase-2 and Reducing Chemokines Levels.Novel ligands that target the mitochondrial membrane protein mitoNEET Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases Discovery of depsides and depsidones from lichen as potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models.Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.Diabetes treatment in 2025: can scientific advances keep pace with prevalence?Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells.Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation.Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-Ay mice and identification of the active ingredients.Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice.Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.

P2860

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P2860

Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma

http://www.wikidata.org/entity/Q24599833

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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type

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Computer-aided discovery, vali ...... rator-activated receptor gamma

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Molecular Pharmacology

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Computer-aided discovery, vali ...... rator-activated receptor gamma

@en

P2093

Elke H Heiss

http://www.w3.org/2001/XMLSchema#string

Ernst P Ellmerer

http://www.w3.org/2001/XMLSchema#string

Lisa Baumgartner

http://www.w3.org/2001/XMLSchema#string

Nanang Fakhrudin

http://www.w3.org/2001/XMLSchema#string

Patrick Markt

http://www.w3.org/2001/XMLSchema#string

P2860

The Protein Data Bank

The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes

Metabolic syndrome and type 2 diabetes mellitus: focus on peroxisome proliferator activated receptors (PPAR)

Structural basis for the activation of PPARgamma by oxidized fatty acids

PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro

'Striking the Right Balance' in Targeting PPARgamma in the Metabolic Syndrome: Novel Insights from Human Genetic Studies

A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation

Natural products as sources of new drugs over the last 25 years

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters.

Fat poetry: a kingdom for PPAR gamma.

P304

559-66

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scholarly article

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593548

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10.1124/MOL.109.062141

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P407

P433

4

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77

http://www.w3.org/2001/XMLSchema#string

P50

Atanas G. Atanasov

Daniela Schuster

Angela Ladurner

Judith M Rollinger

Hermann Stuppner

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2010-04-01T00:00:00Z

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40907565

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20064974

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3523390

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