Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma
about
Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gammaSelected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive CompoundsDiscovery and resupply of pharmacologically active plant-derived natural products: A reviewNatural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a reviewIdentification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gammaHonokiol: a non-adipogenic PPARγ agonist from natureNatural Products to Counteract the Epidemic of Cardiovascular and Metabolic DisordersDrugs from nature targeting inflammation (DNTI): a successful Austrian interdisciplinary network projectMolecular Determinants of Magnolol Targeting Both RXRα and PPARγMetal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABAA receptor ligandsIdentification of PPARgamma partial agonists of natural origin (I): development of a virtual screening procedure and in vitro validationIdentification of PPARgamma partial agonists of natural origin (II): in silico prediction in natural extracts with known antidiabetic activityAccessing biological actions of Ganoderma secondary metabolites by in silico profilingPotential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.Identification of novel liver X receptor activators by structure-based modelingMagnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance.Glycolytic switch in response to betulinic acid in non-cancer cellsPharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidumHit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.n-Hexane Insoluble Fraction of Plantago lanceolata Exerts Anti-Inflammatory Activity in Mice by Inhibiting Cyclooxygenase-2 and Reducing Chemokines Levels.Novel ligands that target the mitochondrial membrane protein mitoNEETModulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory DiseasesDiscovery of depsides and depsidones from lichen as potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models.Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.Diabetes treatment in 2025: can scientific advances keep pace with prevalence?Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells.Linked magnolol dimer as a selective PPARγ agonist - Structure-based rational design, synthesis, and bioactivity evaluation.Hypoglycemic effects of clove (Syzygium aromaticum flower buds) on genetically diabetic KK-Ay mice and identification of the active ingredients.Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice.Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.
P2860
Q21090765-6D12894E-952F-4C14-AE44-4981EFD3D5FCQ21285130-4A10C0D6-CFF8-4439-8C02-122A83BA993BQ22252341-0FB5A8B7-C882-47D9-9469-FEBC05F011E2Q24561401-C026D5BE-BA20-4CFD-BA3E-44B77A5E842DQ24567657-D2BC9683-B15C-4D9B-A5BC-F1F9C2B161E1Q24614114-81D23EEF-3CA3-4C34-9FCE-BAEFEED51E84Q26747523-10253075-B153-49C0-A19C-8A5727417CADQ26749192-7EAFB83A-4B9D-458C-A217-715B5615EF16Q27675984-703C5A26-92BB-4ADC-AAD1-73456183ABE5Q28253925-A3932585-4694-4BF2-B395-0421DEDA79FBQ28485402-99D045EB-3567-4A20-B61B-72745D220A16Q28486003-448C9095-4038-45B2-AAD7-16BE17EA3710Q28829917-13E34E9A-B408-4C1E-9D47-C7FECE2BEDC4Q30847424-F87C4121-1F73-46E2-99CE-B3D7037D97EDQ34054283-752B48EE-659A-4A46-8116-5B7057E40043Q34226831-6649BB4A-7464-430C-880D-17A2A52589D5Q35201406-EA1910E1-DFF4-43BB-B14D-BD71267B8DFEQ35532304-225B1D2B-2463-40CE-93B2-1C78B19BE9BBQ35662134-51E91BCF-AF79-45EE-9450-C36CA8E4D12CQ35967905-DA7DF879-A8AC-49EB-B224-36763348506CQ36320744-EFE6FDC7-66BE-4B35-BC0C-A3F7A88F1A44Q36337739-208CDFAD-3B22-486C-9F1A-CAEE9AF5EA13Q36449677-33787041-BEFD-44EF-843F-9861F5190D55Q36472921-6BA2524B-87A4-4AE6-895B-AE34B5C82E0DQ38263400-921BFC37-F56D-411D-9DE6-24F49C271DF2Q39513531-892404A1-6510-4D5B-AD61-5494B4521049Q42445693-0C8F5408-8624-4448-A33E-75E7E9189A8AQ42652929-626FCC0B-53E1-4FC4-A156-17DAC05942BFQ42804479-E8EA2573-33CD-498D-A482-AB88EDD6CA3BQ50099270-3C1B6204-32BE-4977-A3D9-2FE80F8E85FEQ54506052-5943E7DC-ACDE-4F6A-813C-F49C175873CD
P2860
Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Computer-aided discovery, vali ...... rator-activated receptor gamma
@ast
Computer-aided discovery, vali ...... rator-activated receptor gamma
@en
Computer-aided discovery, vali ...... rator-activated receptor gamma
@nl
type
label
Computer-aided discovery, vali ...... rator-activated receptor gamma
@ast
Computer-aided discovery, vali ...... rator-activated receptor gamma
@en
Computer-aided discovery, vali ...... rator-activated receptor gamma
@nl
prefLabel
Computer-aided discovery, vali ...... rator-activated receptor gamma
@ast
Computer-aided discovery, vali ...... rator-activated receptor gamma
@en
Computer-aided discovery, vali ...... rator-activated receptor gamma
@nl
P2093
P2860
P50
P3181
P356
P1476
Computer-aided discovery, vali ...... rator-activated receptor gamma
@en
P2093
Elke H Heiss
Ernst P Ellmerer
Lisa Baumgartner
Nanang Fakhrudin
Patrick Markt
P2860
P304
P3181
P356
10.1124/MOL.109.062141
P407
P50
P577
2010-04-01T00:00:00Z