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Rett syndrome and MeCP2: linking epigenetics and neuronal function

Rett syndrome and MeCP2: linking epigenetics and neuronal function

http://www.wikidata.org/entity/Q24616417

about

CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction The outdoor air pollution and brain health workshop Rett syndrome: a prototypical neurodevelopmental disorder Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations Unexpected cellular players in Rett syndrome pathology Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia X-linked mental retardation (XLMR): from clinical conditions to cloned genes.Cross talk between microRNA and epigenetic regulation in adult neurogenesis.Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation.DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution.Novel variants identified in methyl-CpG-binding domain genes in autistic individuals.Impact of induced pluripotent stem cells on the study of central nervous system disease MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice.Age-dependent expression of MeCP2 in a heterozygous mosaic mouse model.Characterization of the MeCP2R168X knockin mouse model for Rett syndrome.MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.Epigenetic regulation of neuronal dendrite and dendritic spine development Rett syndrome: the complex nature of a monogenic disease.Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats.CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neurons The molecular genetics of autism spectrum disorders: genomic mechanisms, neuroimmunopathology, and clinical implications The phenotype associated with a large deletion on MECP2.Reading the DNA methylation signal.MeCP2 dysfunction in humans and mice.Dissecting MECP2 function in the central nervous system.Newborn screening and prenatal diagnosis for Rett syndrome: implications for therapy.Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome.Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease Cadmium and its neurotoxic effects Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

http://www.wikidata.org/entity/Q24616417

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2002 nî lūn-bûn

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2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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name

Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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American Journal of Human Genetics

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

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Mona D Shahbazian

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P2860

Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms

Identification and characterization of a family of mammalian methyl-CpG binding proteins

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2.

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

The Ski protein family is required for MeCP2-mediated transcriptional repression

UBE3A/E6-AP mutations cause Angelman syndrome

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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