Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts - Test2 - elhamkhani - TriplyDB

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

http://www.wikidata.org/entity/Q24626938

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Smad7 is required for the development and function of the heart Alpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach Tweaking microtubules to treat scleroderma Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis Animal models of systemic sclerosis: their utility and limitations.Periostin in Mature Stage Localized Scleroderma.The role of ubiquitination and sumoylation in diabetic nephropathy.Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.Ubiquitin-dependent regulation of TGFbeta signaling in cancer Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling.Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4 MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes CD109, a TGF-β co-receptor, attenuates extracellular matrix production in scleroderma skin fibroblasts.Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching.Transforming growth factor β inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis.The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis?Scar wars: is TGFbeta the phantom menace in scleroderma?Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children.Update on pathophysiology of scleroderma with special reference to immunoinflammatory events.Different responses to mechanical injury in neonatal and adult ovine articular cartilage Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex.The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis Pharmacogenomic predictors of citalopram treatment outcome in major depressive disorder.Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities.The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse Mechanisms of skin fibrosis in systemic sclerosis.Animal model of systemic sclerosis.Future treatments in systemic sclerosis.Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.Tyrosine kinase inhibitors in the treatment of systemic sclerosis: from animal models to clinical trials.Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling.Autoimmune mechanisms of scleroderma and a role of oxidative stress.The role of the ubiquitin-proteasome system in kidney diseases.

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P2860

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

http://www.wikidata.org/entity/Q24626938

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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name

Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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type

label

Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

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Journal of Clinical Investigation

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Impaired Smad7-Smurf-mediated ...... ing in scleroderma fibroblasts

@en

P2093

Hironobu Ihn

http://www.w3.org/2001/XMLSchema#string

Kenichi Yamane

http://www.w3.org/2001/XMLSchema#string

Kunihiko Tamaki

http://www.w3.org/2001/XMLSchema#string

Masahide Kubo

http://www.w3.org/2001/XMLSchema#string

Yoshihide Asano

http://www.w3.org/2001/XMLSchema#string

P2860

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

Role of transforming growth factor-beta signaling in cancer

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

Smads: transcriptional activators of TGF-beta responses

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

The transforming growth factor-beta family

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2

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113

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2004-01-01T00:00:00Z

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14722617

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310747

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