A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate - Test2 - elhamkhani - TriplyDB

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate

http://www.wikidata.org/entity/Q24628878

about

Human cytomegalovirus resistance to antiviral drugs How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine Murine cytomegalovirus stimulates cellular thymidylate synthase gene expression in quiescent cells and requires the enzyme for replication Effect of 2'-nor-cyclic GMP against guinea pig cytomegalovirus infection Anti-herpesvirus activities and cytotoxicities of 2-thiopyrimidine nucleoside analogues in vitro Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells Antiviral drug resistance of human cytomegalovirus.Resistance of human cytomegalovirus to antiviral drugs.Clinical uses of cidofovir.Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.Changing therapeutic paradigms in CMV retinitis in AIDS.Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase Efficacy of S26308 against guinea pig cytomegalovirus infection.Resistance of herpesviruses to antiviral drugs A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.Antiviral therapy: current concepts and practices Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus.Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity.Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.Expression of an altered ribonucleotide reductase activity associated with the replication of murine cytomegalovirus in quiescent fibroblasts.The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation.The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine.A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate Exogenous thymidine is preferentially incorporated into human cytomegalovirus DNA in infected human fibroblasts.Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir.Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus.Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections.Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents.Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir.Long term therapy of cytomegalovirus retinitis with ganciclovir in a child with acquired immunodeficiency syndrome.Rapid determination of human cytomegalovirus susceptibility to ganciclovir directly from clinical specimen primocultures.The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein."The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.The impact of drug-resistant cytomegalovirus in pediatric allogeneic hematopoietic cell transplant recipients: a prospective monitoring of UL97 and UL54 gene mutations.Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis.Incidence of Ganciclovir Resistance in CMV-positive Renal Transplant Recipients and its Association with UL97 Gene Mutations.

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P2860

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate

http://www.wikidata.org/entity/Q24628878

description

1986 nî lūn-bûn

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1986 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1986 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1986年の論文

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1986年論文

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1986年論文

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1986年論文

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1986年論文

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1986年論文

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1986年论文

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name

A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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type

label

A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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PNAS.83.22.8769

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Proceedings of the National Academy of Sciences of the United States of America

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A human cytomegalovirus mutant ...... evels of BW B759U triphosphate

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C U Lambe

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D M Coen

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J A Fyfe

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J B Sorrell

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L K Leslie

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P2860

Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine

Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses

Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1

9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication

Molecular engineering of the herpes simplex virus genome: insertion of a second L-S junction into the genome causes additional genome inversions.

Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters.

Nucleic acid hybridization for measurement of effects of antiviral compounds on human cytomegalovirus DNA replication.

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

Effects of deletions on expression of the herpes simplex virus thymidine kinase gene from the intact viral genome: the amino terminus of the enzyme is dispensable for catalytic activity.

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8769-73

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10.1073/PNAS.83.22.8769

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22

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83

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20134585

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3022304

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Cytomegalovirus

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387013

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