Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
about
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathyRad GTPase deficiency leads to cardiac hypertrophyL-type calcium channel targeting and local signalling in cardiac myocytesStructure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channelsActivity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαStructure of the GDP-bound G domain of the RGK protein Rem2Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channelsThe ß subunit of voltage-gated Ca2+ channelsComprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout miceT-type calcium channel blockers as neuroprotective agents.Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interactionAblation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memoryA loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexityThe beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6.Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscleHuman RAS superfamily proteins and related GTPases.Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond.Bio-inspired voltage-dependent calcium channel blockersMice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handlingRGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes.Topological and functional properties of the small GTPases protein interaction network.Crystal structure of human Rad GTPase of the RGK-family.Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivationPlasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers.Alone at last! New functions for Ca2+ channel beta subunits?Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channelsRem-GTPase regulates cardiac myocyte L-type calcium current.Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPasesVascular calcium channels and high blood pressure: pathophysiology and therapeutic implications.The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.
P2860
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P2860
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@ast
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@en
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@nl
type
label
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@ast
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@en
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@nl
prefLabel
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@ast
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@en
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@nl
P2093
P2860
P3181
P356
P1476
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases
@en
P2093
Brian S Finlin
Douglas A Andres
Jonathan Satin
Shawn M Crump
P2860
P304
P3181
P356
10.1073/PNAS.2437756100
P407
P577
2003-11-25T00:00:00Z