Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases - Test2 - elhamkhani - TriplyDB

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

http://www.wikidata.org/entity/Q24630460

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Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy Rad GTPase deficiency leads to cardiac hypertrophy L-type calcium channel targeting and local signalling in cardiac myocytes Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIα Structure of the GDP-bound G domain of the RGK protein Rem2 Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels The ß subunit of voltage-gated Ca2+ channels Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice T-type calcium channel blockers as neuroprotective agents.Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6.Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscle Human RAS superfamily proteins and related GTPases.Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond.Bio-inspired voltage-dependent calcium channel blockers Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes.Topological and functional properties of the small GTPases protein interaction network.Crystal structure of human Rad GTPase of the RGK-family.Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers.Alone at last! New functions for Ca2+ channel beta subunits?Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels Rem-GTPase regulates cardiac myocyte L-type calcium current.Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications.The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.

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P2860

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

http://www.wikidata.org/entity/Q24630460

description

2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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prefLabel

Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Proceedings of the National Academy of Sciences of the United States of America

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Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases

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Brian S Finlin

http://www.w3.org/2001/XMLSchema#string

Douglas A Andres

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Jonathan Satin

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Shawn M Crump

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P2860

T-type alpha 1H Ca2+ channels are involved in Ca2+ signaling during terminal differentiation (fusion) of human myoblasts

Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family

Gem: an induced, immediate early protein belonging to the Ras family

Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

A simplified system for generating recombinant adenoviruses

Nerve growth factor-dependent activation of the small GTPase Rin

Structure and regulation of voltage-gated Ca2+ channels

Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins

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14469-74

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scholarly article

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10.1073/PNAS.2437756100

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24

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100

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9003239

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14623965

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283615

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