Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice
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Ion Channels in Obesity: Pathophysiology and Potential Therapeutic TargetsMitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1.3 ion channelUbiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targetingHyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning.Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.Kv1.3: a potential pharmacological target for diabetes.Olfaction under metabolic influences.Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3.State-dependent sculpting of olfactory sensory neurons is attributed to sensory enrichment, odor deprivation, and aging.Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a.Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent.Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseasesOlfactory ability and object memory in three mouse models of varying body weight, metabolic hormones, and adiposity.The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity.The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel.Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.Voltage-gated potassium channels as therapeutic targets.Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy.The Olfactory Bulb: A Metabolic Sensor of Brain Insulin and Glucose Concentrations via a Voltage-Gated Potassium Channel.Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3.Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies.Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice.Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.Spiro azepane-oxazolidinones as Kv1.3 potassium channel blockers: WO2010066840.Expression of Kv1.3 potassium channels regulates density of cortical interneuronsGlucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors.Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice.A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish.
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P2860
Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice
description
2008 nî lūn-bûn
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2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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type
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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prefLabel
Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
@ast
Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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Kv1.3 gene-targeted deletion a ...... anocortin-4 receptor-null mice
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10.1038/IJO.2008.77
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2008-08-01T00:00:00Z
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1026443897