Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism - Test2 - elhamkhani - TriplyDB

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism

http://www.wikidata.org/entity/Q24644811

about

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation The great escape: viral strategies to counter BST-2/tetherin The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu BST2/Tetherin enhances entry of human cytomegalovirus Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin Rab7A is required for efficient production of infectious HIV-1 Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1 Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain Cell-to-cell transmission of retroviruses: Innate immunity and interferon-induced restriction factors The restriction factors of human immunodeficiency virus How SAMHD1 changes our view of viral restriction HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin BST-2/tetherin: a new component of the innate immune response to enveloped viruses Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus The role of BST-2/Tetherin in host protection and disease manifestation Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence Vpu Protein: The Viroporin Encoded by HIV-1 Viral Membrane Channels: Role and Function in the Virus Life Cycle Tetherin restricts productive HIV-1 cell-to-cell transmission Structural insight into the mechanisms of enveloped virus tethering by tetherin Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradation Mechanism of HIV-1 virion entrapment by tetherin Intrinsic cellular defenses against human immunodeficiency viruses Counteraction of the multifunctional restriction factor tetherin Vpu and BST2: Still Not There Yet?Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release Differential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Modulation of HIV-1-host interaction: role of the Vpu accessory protein Lack of adaptation to human tetherin in HIV-1 group O and P.Animal models for HIV/AIDS research Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function

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P2860

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism

http://www.wikidata.org/entity/Q24644811

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Vpu directs the degradation of ...... {beta}TrCP-dependent mechanism

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Ashlee V Moses

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Janet L Douglas

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Jean K Gustin

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Kasinath Viswanathan

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Klaus Früh

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Matthew N McCarroll

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P2860

Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor

Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth

Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments

Identification of gammaretroviruses constitutively released from cell lines used for human immunodeficiency virus research

Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation

The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation

The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels

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7931-47

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scholarly article

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2798904

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10.1128/JVI.00242-09

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16

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83

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2009-08-01T00:00:00Z

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19515779

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2715753

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