The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
about
Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop adaptability in selective inhibition of bacterial enzymesHeterologous expression and purification of Vibrio proteolyticus (Aeromonas proteolytica) aminopeptidase: A rapid protocolStructure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470Hydroxamic acids as potent inhibitors of Fe(II) and Mn(II) E. coli methionine aminopeptidase: biological activities and X-ray structures of oxazole hydroxamate-EcMetAP-Mn complexesAntifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionCobalt proteins.Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity.Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase.Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model.A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidasesMutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosisStructurally distinct active sites in the copper(II)-substituted aminopeptidases from Aeromonas proteolytica and Escherichia coliMutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli.Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli.Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli.Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.Identifying the cellular targets of natural products using T7 phage display.Probing the metal ion selectivity in methionine aminopeptidase via changes in the luminescence properties of the enzyme bound europium ionAntiangiogenic nanotherapy with lipase-labile Sn-2 fumagillin prodrugYeast methionine aminopeptidase I. Alteration of substrate specificity by site-directed mutagenesis.The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism.Quality not Quantity: The Role of Marine Natural Products in Drug Discovery and Reverse Chemical Proteomics.Biochemical characterization of recombinant methionine aminopeptidases (MAPs) from Mycobacterium tuberculosis H37Rv.
P2860
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P2860
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@ast
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@en
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@nl
type
label
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@ast
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@en
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@nl
prefLabel
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@ast
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@en
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@nl
P2093
P2860
P356
P1476
The anti-angiogenic agent fuma ...... coli methionine aminopeptidase
@en
P2093
B W Matthews
D A McMillen
W T Lowther
P2860
P304
12153-12157
P356
10.1073/PNAS.95.21.12153
P407
P577
1998-10-01T00:00:00Z