Positive selection acting on splicing motifs reflects compensatory evolution
about
Weak selection and protein evolutionOrigin and evolution of spliceosomal intronsImpairment of translation in neurons as a putative causative factor for autismRethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modificationsBoth Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution.The salmonid myostatin gene family: a novel model for investigating mechanisms that influence duplicate gene fate.siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer.Evolution of alternative splicing regulation: changes in predicted exonic splicing regulators are not associated with changes in alternative splicing levels in primates.Evidence of uneven selective pressure on different subsets of the conserved human genome; implications for the significance of intronic and intergenic DNA.Exonic splicing signals impose constraints upon the evolution of enzymatic activity.Genomic features defining exonic variants that modulate splicing.Evolution of alternative splicing in primate brain transcriptomes.Nonsense mutation-associated Becker muscular dystrophy: interplay between exon definition and splicing regulatory elements within the DMD gene.Genomic HEXploring allows landscaping of novel potential splicing regulatory elements.Divergence of exonic splicing elements after gene duplication and the impact on gene structures.COMIT: identification of noncoding motifs under selection in coding sequences.Splicing of designer exons informs a biophysical model for exon definitionStatistics and truth in phylogenomics.The Silent Sway of Splicing by Synonymous SubstitutionsRNA landscape of evolution for optimal exon and intron discrimination.Exon creation and establishment in human genesGenome-wide analysis of alternative transcripts in human breast cancer.Complex selection on 5' splice sites in intron-rich organisms.A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele.Pathogenic variants that alter protein code often disrupt splicing.Succession of splicing regulatory elements determines cryptic 5΄ss functionality.Context-dependent splicing regulation: exon definition, co-occurring motif pairs and tissue specificityIntronic splicing enhancers, cognate splicing factors and context-dependent regulation rulesDisease-causing mutations improving the branch site and polypyrimidine tract: pseudoexon activation of LINE-2 and antisense Alu lacking the poly(T)-tail.Intronic motif pairs cooperate across exons to promote pre-mRNA splicing.Quantitative evaluation of all hexamers as exonic splicing elementsIntrons Structure Patterns of Variation in Nucleotide Composition in Arabidopsis thaliana and Rice Protein-Coding Genes.Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci.Saturation mutagenesis reveals manifold determinants of exon definition.Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis.Exonic splice regulation imposes strong selection at synonymous sites
P2860
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P2860
Positive selection acting on splicing motifs reflects compensatory evolution
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Positive selection acting on splicing motifs reflects compensatory evolution
@ast
Positive selection acting on splicing motifs reflects compensatory evolution
@en
Positive selection acting on splicing motifs reflects compensatory evolution
@nl
type
label
Positive selection acting on splicing motifs reflects compensatory evolution
@ast
Positive selection acting on splicing motifs reflects compensatory evolution
@en
Positive selection acting on splicing motifs reflects compensatory evolution
@nl
prefLabel
Positive selection acting on splicing motifs reflects compensatory evolution
@ast
Positive selection acting on splicing motifs reflects compensatory evolution
@en
Positive selection acting on splicing motifs reflects compensatory evolution
@nl
P2860
P356
P1433
P1476
Positive selection acting on splicing motifs reflects compensatory evolution
@en
P2093
Lawrence A Chasin
P2860
P304
P356
10.1101/GR.070268.107
P407
P577
2008-01-18T00:00:00Z