Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
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Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisDualPhos: a versatile, chemoselective reagent for two-carbon aldehyde to latent (E)-alkenal homologation and application in the total synthesis of phomolide GDesigned, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroTotal synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityDevelopment of a general, sequential, ring-closing metathesis/intramolecular cross-coupling reaction for the synthesis of polyunsaturated macrolactonesTotal synthesis of bryostatin 9Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisEnantioselective Alcohol C-H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis.Total synthesis of bryostatin 1A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals.Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopy"Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Brønsted acid catalyzed asymmetric propargylation of aldehydesTotal syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment.Atom-economic and stereoselective syntheses of the ring a and B subunits of the bryostatins.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization StrategyToward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.Assembly of long error-prone reads using de Bruijn graphs.Total synthesis of (-)-18-epi-peloruside A: an alkyne linchpin strategy.Neurotrophic natural products: chemistry and biology.Chemoselectivity and the curious reactivity preferences of functional groups.Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiencyProbing the biology of natural products: molecular editing by diverted total synthesis.Gold catalysis in total synthesis--an update.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Strategic innovation in the total synthesis of complex natural products using gold catalysis.Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.Toward the ideal synthesis and molecular function through synthesis-informed design.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy.Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities.Transition metal-catalyzed couplings of alkynes to 1,3-enynes: modern methods and synthetic applications.
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P2860
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@ast
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@en
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@nl
type
label
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@ast
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@en
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@nl
prefLabel
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@ast
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@en
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@nl
P2860
P356
P1433
P1476
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches
@en
P2093
Guangbin Dong
P2860
P2888
P356
10.1038/NATURE07543
P407
P50
P577
2008-11-27T00:00:00Z
P5875
P6179
1046948455