Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction - Test2 - elhamkhani - TriplyDB

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

http://www.wikidata.org/entity/Q24650734

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The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation Interleukin-2 receptor signaling: at the interface between tolerance and immunity IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation The PD-1 pathway in tolerance and autoimmunity Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes Inducing and Administering Tregs to Treat Human Disease Inflammatory cytokines in systemic lupus erythematosus Application of IL-2 therapy to target T regulatory cell function Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs Insights into type 1 diabetes from the autoimmune polyendocrine syndromes Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines Organ-specific and memory treg cells: specificity, development, function, and maintenance Regulatory T-cell therapy in transplantation: moving to the clinic IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives Manipulating regulatory T cells: a promising strategy to treat autoimmunity Genetics, pathogenesis and clinical interventions in type 1 diabetes Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy.Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells.Restoring the balance: immunotherapeutic combinations for autoimmune disease Once a Treg, always a Treg?Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection Peripherally Induced Regulatory T Cells: Recruited Protectors of the Central Nervous System against Autoimmune Neuroinflammation.Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes.IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions Regulatory T cells and myeloid-derived suppressor cells in the tumor microenvironment undergo Fas-dependent cell death during IL-2/αCD40 therapy

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P2860

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

http://www.wikidata.org/entity/Q24650734

description

2008 nî lūn-bûn

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2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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Central role of defective inte ...... f islet autoimmune destruction

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J.IMMUNI.2008.03.016

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Central role of defective inte ...... f islet autoimmune destruction

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Ciriaco A Piccirillo

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Cristina Penaranda

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Evridiki Sgouroudis

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Jason Y Adams

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Jeffrey A Bluestone

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Kristin Melli

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Qizhi Tang

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P2860

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Breeding of a non-obese, diabetic strain of mice

Multiple immuno-regulatory defects in type-1 diabetes

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

A function for interleukin 2 in Foxp3-expressing regulatory T cells

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.

Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients.

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687-697

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10.1016/J.IMMUNI.2008.03.016

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5

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Benoit L Salomon

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5384065

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18468463

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infectious disease

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2394854

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