Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?
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Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J micePDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.Enhancement of the anti-inflammatory and anti-arthritic effects of theophylline by a low dose of a nitric oxide donor or non-specific nitric oxide synthase inhibitorApremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β 2-adrenoceptor agonist in preclinical animal species.Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness.Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammationHesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced AnesthesiaSuzuki-Miyaura cross-coupling of potassium trifluoro(N-methylheteroaryl)borates with aryl and heteroaryl halides.Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.An imbalance in C/EBPs and increased mitochondrial activity in asthmatic airway smooth muscle cells: novel targets in asthma therapy?Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.PDE4 inhibitors: a review of current developments (2005 - 2009).Clinical and molecular genetics of the phosphodiesterases (PDEs).Mitochondria in lung diseases.Treatment of chronic obstructive pulmonary disease with roflumilast, a new phosphodiesterase 4 inhibitor.Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary diseaseModulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states.Multifunctional dendritic polymers in nanomedicine: opportunities and challenges.Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction.Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis: Progress and Outlook.The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation.Simulations suggest pharmacological methods for rescuing long-term potentiation.Anti-inflammatory effects of selected drugs on activated neonatal and adult neutrophils.Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways.Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference.Emerging drugs for psoriasis
P2860
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P2860
Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@ast
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@en
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@nl
type
label
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@ast
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@en
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@nl
prefLabel
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@ast
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@en
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@nl
P2860
P3181
P356
P1476
Can the anti-inflammatory pote ...... optimism or wishful thinking?
@en
P2093
M A Giembycz
P2860
P304
P3181
P356
10.1038/BJP.2008.297
P407
P577
2008-10-01T00:00:00Z