Crystal structure of an RNA aptamer bound to thrombin - Test2 - elhamkhani - TriplyDB

Crystal structure of an RNA aptamer bound to thrombin

Crystal structure of an RNA aptamer bound to thrombin

http://www.wikidata.org/entity/Q24652403

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Expected and unexpected features of protein-binding RNA aptamers Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection Nucleic acid aptamers: an emerging frontier in cancer therapy A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1 Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer Aptamer-Drug Conjugates Probing the limits of aptamer affinity with a microfluidic SELEX platform RNA plasticity and selectivity applicable to therapeutics and novel biosensor development Modulation of the Coagulation Cascade Using Aptamers An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism.Artificial specific binders directly recovered from chemically modified nucleic acid libraries.New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization.Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterials Using azobenzene incorporated DNA aptamers to probe molecular binding interactions.Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites Computational selection of RNA aptamer against angiopoietin-2 and experimental evaluation Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.SELEX Modifications and Bioanalytical Techniques for Aptamer-Target Binding Characterization.DNA display of folded RNA libraries enabling RNA-SELEX without reverse transcription.Aptamers can discriminate alkaline proteins with high specificity.In silico selection of an aptamer to estrogen receptor alpha using computational docking employing estrogen response elements as aptamer-alike molecules.Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase.Evoking picomolar binding in RNA by a single phosphorodithioate linkage.Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.An RNA aptamer possessing a novel monovalent cation-mediated fold inhibits lysozyme catalysis by inhibiting the binding of long natural substrates.High-content affinity-based proteomics: unlocking protein biomarker discovery.Characterization of aptamer-protein complexes by X-ray crystallography and alternative approaches.Application of aptamers for targeted therapeutics.Towards XNA nanotechnology: new materials from synthetic genetic polymers Determining Functional Aptamer-Protein Interaction by Biolayer Interferometry.Nucleic acid aptamers in cancer research, diagnosis and therapy.Salt bridge exchange binding mechanism between streptavidin and its DNA aptamer--thermodynamics and spectroscopic evidences.A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.Dependence of aptamer activity on opposed terminal extensions: improvement of light-regulation efficiency.

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P2860

Crystal structure of an RNA aptamer bound to thrombin

http://www.wikidata.org/entity/Q24652403

description

2008 nî lūn-bûn

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2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Crystal structure of an RNA aptamer bound to thrombin

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Crystal structure of an RNA aptamer bound to thrombin

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Crystal structure of an RNA aptamer bound to thrombin

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type

label

Crystal structure of an RNA aptamer bound to thrombin

@ast

Crystal structure of an RNA aptamer bound to thrombin

@en

Crystal structure of an RNA aptamer bound to thrombin

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prefLabel

Crystal structure of an RNA aptamer bound to thrombin

@ast

Crystal structure of an RNA aptamer bound to thrombin

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Crystal structure of an RNA aptamer bound to thrombin

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Crystal structure of an RNA aptamer bound to thrombin

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Bruce A Sullenger

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Meredith B Long

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Rebekah R White

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Stephen B Long

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P2860

Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha

RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution)

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

The structural basis for molecular recognition by the vitamin B 12 RNA aptamer

Refinement of the solution structure of the heparin-binding domain of vascular endothelial growth factor using residual dipolar couplings

Encapsulating streptomycin within a small 40-mer RNA

Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

Crystal structure of NF- B (p50)2 complexed to a high-affinity RNA aptamer

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

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3863221

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10.1261/RNA.1239308

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12

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14

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18971322

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crystal structure

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