The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism - Test2 - elhamkhani - TriplyDB

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

http://www.wikidata.org/entity/Q24654815

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Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4 Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals.The varied roles of nuclear receptors during vertebrate embryonic development.Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3 Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α Ligand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha ).Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity.Dynamic regulation of Drosophila nuclear receptor activity in vivo.HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus.Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates Many faces of monogenic diabetes Hepatocyte nuclear factor 4{alpha} regulates rifampicin-mediated induction of CYP2C genes in primary cultures of human hepatocytes The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice.Dissecting the transcriptional network of pancreatic islets during development and differentiation.A transcription factor regulatory circuit in differentiated pancreatic cells.Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells.SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes Gene expression profile analysis of type 2 diabetic mouse liver.Stress responsive proteins are actively regulated during rice (Oryza sativa) embryogenesis as indicated by quantitative proteomics analysis Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in French-Canadian youth PGC-1alpha controls hepatitis B virus through nutritional signals Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis Impairment of hepatic nuclear factor-4α binding to the Stim1 promoter contributes to high glucose-induced upregulation of STIM1 expression in glomerular mesangial cells Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update.

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The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

http://www.wikidata.org/entity/Q24654815

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1997 nî lūn-bûn

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1997年の論文

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1997年論文

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1997年論文

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1997年论文

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Proceedings of the National Academy of Sciences of the United States of America

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The maturity-onset diabetes of ...... ucose transport and metabolism

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M Stoffel

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S A Duncan

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A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells

Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

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9371825

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