Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate
about
Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gammaThe proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activityDendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ releaseModulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity.Cell surface topology creates high Ca2+ signalling microdomains.A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration.Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus.Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gatingA TRP channel contributes to insulin secretion by pancreatic β-cells.Inactivation of TRPM2 channels by extracellular divalent copper.Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents.Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channelsTransient potential receptor melastatin-2 (Trpm2) does not influence murine MLL-AF9-driven AML leukemogenesis or in vitro response to chemotherapy.TRPM2: a multifunctional ion channel for calcium signalling.TRPM2, calcium and neurodegenerative diseases.The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation.Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells.Redox regulation of transient receptor potential channels in the endothelium.Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8.Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice.Activators of TRPM2: Getting it right.Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity.Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2.Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone.2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.Development of novel and non-invasive diagnostic markers for lower urinary tract symptoms using urothelial cells in voided urine.TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain.Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity.A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH
P2860
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P2860
Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@ast
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@en
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@nl
type
label
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@ast
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@en
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@nl
prefLabel
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@ast
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@en
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@nl
P2860
P3181
P356
P1476
Four Ca2+ ions activate TRPM2 ...... ut intracellularly of the gate
@en
P2093
Beáta Törocsik
P2860
P304
P3181
P356
10.1085/JGP.200810109
P407
P577
2009-02-01T00:00:00Z