Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta
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Dual regulation of mu opioid receptors in SK-N-SH neuroblastoma cells by morphine and interleukin-1β: evidence for opioid-immune crosstalkEvidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activityCXCR4 signaling mediates morphine-induced tactile hyperalgesia.Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine PathologyInteractions of Opioids and HIV Infection in the Pathogenesis of Chronic PainOpioid-induced central immune signaling: implications for opioid analgesiaGlucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced painBiphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.Toll-like Receptor-Dependent Negative Effects of Opioids: A Battle between Analgesia and Hyperalgesia.(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats.Opioid activation of toll-like receptor 4 contributes to drug reinforcementActivation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelaeSelect steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced painStress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.Microglia: a promising target for treating neuropathic and postoperative pain, and morphine toleranceAlcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling.Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study.Toll-like receptors in chronic pain.Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidasePharmacology of nonsteroidal antiinflammatory drugs and opioidsMorphine activates neuroinflammation in a manner parallel to endotoxinAcute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice.Analgesia or addiction?: implications for morphine use after spinal cord injury.Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer ratsBlockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model.Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling.Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients.Ultralow Dose of Naloxone as an Adjuvant to Intrathecal Morphine Infusion Improves Perceived Quality of Sleep but Fails to Alter Persistent Pain: A Randomized, Double-blind, Controlled Study.Blockade of Toll-like receptor 4 attenuates morphine tolerance and facilitates the pain relieving properties of morphineEvaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury.Why is neuroimmunopharmacology crucial for the future of addiction research?The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro.A structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach.Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain.Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse.Roles of reactive oxygen and nitrogen species in painTetracyclines and pain.Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasisTransgene-mediated expression of tumor necrosis factor soluble receptor attenuates morphine tolerance in rats.
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P2860
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta
description
2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@ast
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@en
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@nl
type
label
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@ast
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@en
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@nl
prefLabel
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@ast
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@en
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@nl
P2093
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P1476
Evidence that intrathecal morp ...... r 4/MD-2 and interleukin-1beta
@en
P2093
L R Watkins
M R Hutchinson
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P304
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P356
10.1016/J.NEUROSCIENCE.2009.10.011
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P577
2010-01-20T00:00:00Z