Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs - Test2 - elhamkhani - TriplyDB

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

http://www.wikidata.org/entity/Q24657987

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Perioperative Red Blood Cell Transfusion: What We Do Not Know Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions Transfusion of Old RBCs Induces Neuroinflammation and Cognitive Impairment.Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units Molecular controls of the oxygenation and redox reactions of hemoglobin Acetaminophen attenuates lipid peroxidation in children undergoing cardiopulmonary bypass Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.Angiotensin-converting enzyme inhibitor captopril reverses the adverse cardiovascular effects of polymerized hemoglobin.The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions.Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.Pleiotropic effects of intravascular haemolysis on vascular homeostasis.Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.Blood substitutes: why haven't we been more successful?Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol Proximal tubule haptoglobin gene activation is an integral component of the acute kidney injury "stress response".Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)Understanding the erythrocyte storage lesion.A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia.α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins Cell-free hemoglobin: a novel mediator of acute lung injury Examining and mitigating acellular hemoglobin vasoactivity.Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145 Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes.Acute phase reactants as novel predictors of cardiovascular disease.Abundance of plasma antioxidant proteins confers tolerance to acute hypobaric hypoxia exposure.Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.Haptoglobin halts hemoglobin's havoc.Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock

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P2860

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

http://www.wikidata.org/entity/Q24657987

description

2009 nî lūn-bûn

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2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Sequestration of extracellular ...... ffects in dogs and guinea pigs

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Journal of Clinical Investigation

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Sequestration of extracellular ...... ffects in dogs and guinea pigs

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Abdu I Alayash

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Claudia P Pereira

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Felice D'Agnillo

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Felicitas S Boretti

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Gabriele Schoedon

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Jeroen Goede

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Katharina Kluge

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Marco Maggiorini

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Omer I Butt

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Paul W Buehler

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P2860

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis

Enhancement of platelet function by superoxide anion

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice

Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways.

The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.

Identification of the haemoglobin scavenger receptor.

Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.

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2271-2280

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10.1172/JCI39115

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8

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119

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2009-07-20T00:00:00Z

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19620788

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2719941

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