Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 - Test2 - elhamkhani - TriplyDB

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

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Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene Genetic analysis of OCT1 gene polymorphisms in an Indian population A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries The role of variants regulating metformin transport and action in women with polycystic ovary syndrome.Genetic diversity and function in the human cytosolic sulfotransferases.Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol.Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.The use of orthologous sequences to predict the impact of amino acid substitutions on protein function.PharmGKB summary: very important pharmacogene information for SLC22A1 Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Molecular modeling and ligand docking for solute carrier (SLC) transporters Stereoselective binding of chiral ligands to single nucleotide polymorphisms of the human organic cation transporter-1 determined using cellular membrane affinity chromatography.Comparison of human solute carriers Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.An update on the pharmacogenomics of metformin: progress, problems and potential.Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.Uptake of pramipexole by human organic cation transporters.Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study.Functional genomics of membrane transporters in human populations.The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.The pharmacogenetics of imanitib.Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.Natural variation in human membrane transporter genes reveals evolutionary and functional constraints Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1)Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action Pharmacogenetics of metformin response: a step in the path toward personalized medicine Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.Molecular and cellular physiology of renal organic cation and anion transport.Characterization of Disease-Associated Mutations in Human Transmembrane Proteins Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1).Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy.

P2860

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P2860

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

http://www.wikidata.org/entity/Q24675093

description

2003 nî lūn-bûn

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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type

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Proceedings of the National Academy of Sciences of the United States of America

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Evolutionary conservation pred ...... ganic cation transporter, OCT1

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Bo Feng

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Conrad C Huang

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Doug Stryke

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Elaine Carlson

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Ira Herskowitz

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Joseph DeYoung

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Maya K Leabman

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Michiko Kawamoto

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Susan J Johns

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P2860

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

Predicting deleterious amino acid substitutions

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

Cloning and functional expression of a human liver organic cation transporter

Cloning and characterization of two human polyspecific organic cation transporters

Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome

Amino acid substitution matrices from protein blocks

A New Statistical Method for Haplotype Reconstruction from Population Data

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

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