Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes - Test2 - elhamkhani - TriplyDB

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

http://www.wikidata.org/entity/Q24675937

about

Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells Pmel17 initiates premelanosome morphogenesis within multivesicular bodies Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4 Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes Identification and functional characterization of a TIA-1-related nucleolysin LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions B lymphocytes secrete antigen-presenting vesicles Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis Protein kinase activity is associated with CD63 in melanoma cells.Exosomes: The Link between GPCR Activation and Metastatic Potential?Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges Lysosome-Related Effector Vesicles in T Lymphocytes and NK Cells Regulation of immune responses by extracellular vesicles Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells Visualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme B Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse SHP-1 phosphatase is a critical regulator in preventing natural killer cell self-killing Behavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes Prion uptake in the gut: identification of the first uptake and replication sites Biology, Therapy and Implications of Tumor Exosomes in the Progression of Melanoma Normal lysosomal morphology and function in LAMP-1-deficient mice Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface Antigen distribution of TMUV and GPV are coincident with the expression profiles of CD8α-positive cells and goose IFNγ.Role of CD8(+) T-cell immunity in influenza infection: potential use in future vaccine development.CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.Imaging effector functions of human cytotoxic CD4+ T cells specific for Plasmodium falciparum circumsporozoite protein.Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.Enrichment and analysis of secretory lysosomes from lymphocyte populations Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients

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P2860

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

http://www.wikidata.org/entity/Q24675937

description

1991 nî lūn-bûn

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1991 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1991 թվականի մայիսին հրատարակված գիտական հոդված

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1991年の論文

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1991年論文

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1991年論文

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1991年論文

@zh-hk

1991年論文

@zh-mo

1991年論文

@zh-tw

1991年论文

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name

Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

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Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

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Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

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type

label

Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

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Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

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Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

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prefLabel

Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

@ast

Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

@en

Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

@nl

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Journal of Experimental Medicine

P1476

Cytotoxic T lymphocyte granule ...... ng both perforin and granzymes

@en

P2093

H J Geuze

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J Borst

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J Tschopp

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J W Slot

http://www.w3.org/2001/XMLSchema#string

M Fukuda

http://www.w3.org/2001/XMLSchema#string

O Krähenbühl

http://www.w3.org/2001/XMLSchema#string

P J Peters

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V Oorschot

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P2860

Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan

Characterization of three serine esterases isolated from human IL-2 activated killer cells

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes

The biogenesis of lysosomes

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.

Inhibition of lymphocyte mediated cytotoxicity by perforin antisense oligonucleotides.

Homology of perforin to the ninth component of complement (C9).

Structure and function of human perforin.

Two proteins targeted to the same lytic granule compartment undergo very different posttranslational processing.

P304

1099-109

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scholarly article

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1810989

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10.1084/JEM.173.5.1099

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5

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173

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1991-05-01T00:00:00Z

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270919696

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P698

2022921

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P921

P932

2118839

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