The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation - Test2 - elhamkhani - TriplyDB

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

http://www.wikidata.org/entity/Q24678674

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Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation Copine-III interacts with ErbB2 and promotes tumor cell migration An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells Breast cancer in the personal genomics era FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis The PI3K pathway as drug target in human cancer Suppression of cell growth and invasion by miR-205 in breast cancer Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1 Essential function for ErbB3 in breast cancer proliferation Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data.Mechanisms of resistance and sensitivity to anti-HER2 therapies in HER2+ breast cancer Analysis of different HER-2 mutations in breast cancer progression and drug resistance A paradigm shift: Cancer therapy with peptide-based B-cell epitopes and peptide immunotherapeutics targeting multiple solid tumor types: Emerging concepts and validation of combination immunotherapy Structure-function relationships of ErbB RTKs in the plasma membrane of living cells Targeting of erbB3 receptor to overcome resistance in cancer treatment Current treatment of early breast cancer: adjuvant and neoadjuvant therapy Lipid biology of breast cancer Quantification of HER family receptors in breast cancer Regulation of ERBB3/HER3 signaling in cancer HER2 as a therapeutic target in head and neck squamous cell carcinoma Orchestration of ErbB3 signaling through heterointeractions and homointeractions.Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin Comparative analysis of the Tyr-kinases CapB1 and CapB2 fused to their cognate modulators CapA1 and CapA2 from Staphylococcus aureus Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.ErbB2 signaling at the crossing between heart failure and cancer Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling A comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cells The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling

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The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

http://www.wikidata.org/entity/Q24678674

description

2003 nî lūn-bûn

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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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Proceedings of the National Academy of Sciences of the United States of America

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The ErbB2/ErbB3 heterodimer fu ...... reast tumor cell proliferation

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Carlos F Barbas

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Francisca Maurer

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Magdalena Koziczak

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Nancy E Hynes

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Roger R Beerli

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Thomas Holbro

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P2860

Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

Positive and negative regulation of endogenous genes by designed transcription factors

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

Untangling the ErbB signalling network

Engineering polydactyl zinc-finger transcription factors

Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas

Epidermal growth factor-related peptides and their receptors in human malignancies

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100

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