Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
about
Life cycle of connexins in health and diseaseConnexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposing hemiplaques, forming bihomotypic gap junctions, with scaffolding contributed by zonula occludens-1Gap junctions in inherited human disorders of the central nervous system.The role of Eph receptors in lens function and diseaseLoss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataractAssociation of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retinaThe tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lensA novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.Transgenic overexpression of connexin50 induces cataracts.Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain.Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.Connexin43 PDZ2 binding domain mutants create functional gap junctions and exhibit altered phosphorylationAmino acid residue Val362 plays a critical role in maintaining the structure of C terminus of connexin 50 and in lens epithelial-fiber differentiationMechanisms of gap junction traffic in health and diseaseZonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretionCell-autonomous requirements for Dlg-1 for lens epithelial cell structure and fiber cell morphogenesis.Ectopic activation of Wnt/β-catenin signaling in lens fiber cells results in cataract formation and aberrant fiber cell differentiation.Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion.The carboxyl tail of connexin32 regulates gap junction assembly in human prostate and pancreatic cancer cells.Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells.The connexin43 carboxyl terminus and cardiac gap junction organizationNeuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1)Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testesLens gap junctions in growth, differentiation, and homeostasis.Focus on lens connexins.Protein kinase A mediates regulation of gap junctions containing connexin35 through a complex pathway.Polarity proteins as regulators of cell junction complexes: implications for breast cancer.Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization.ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43Reciprocal influence of connexins and apical junction proteins on their expressions and functions.Discovering the molecular components of intercellular junctions--a historical view.The membrane proteome of the mouse lens fiber cell.Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism.Dual function of Yap in the regulation of lens progenitor cells and cellular polarity.Knock-in of Cx46 partially rescues fiber defects in lenses lacking Cx50New aspects of the molecular constituents of tissue barriers.Biological glass: structural determinants of eye lens transparencyThe cell adhesion gene PVRL3 is associated with congenital ocular defects.
P2860
Q24541428-54A45E62-67D9-4FD4-8BA2-18E00F92BF0BQ24655949-6496A819-586C-4A7E-A7F2-ADA4EBE302D3Q26823332-5035110B-2A6B-4C8A-991E-6632FE683E0DQ27007359-EB677FC8-16AA-4D46-882C-BA17AEE87288Q28508868-DBD264B7-2B03-47D2-B41A-A613AFA026ADQ28582084-0AC0A5C1-BC00-4B03-ACB6-D087F534CA1DQ28590774-B751F566-C2E0-4BE9-9756-C6FFC5FD6785Q30402445-C8693EE6-D5CF-4FF5-A3F6-9852E233C711Q30479349-8E3FF299-21BA-472B-A447-8A346BC5A24DQ30499651-FC8E61DB-A1BD-4373-932A-D8A0FEFCF750Q33285744-94C57580-3472-481A-B66D-2BE581B78D04Q33894616-A6CD9612-3DF1-4B85-9B73-B47BDC0BBEFBQ33897784-E57D9E79-BF1F-4745-8391-44EC9B9C840DQ34017761-B7A3002F-CD4F-48A8-B328-A448D17CB770Q34148181-195B8F9C-14C1-494E-83BB-91B50FAD0010Q34467050-3D3AB98E-EAA7-4ACB-BFD9-2F32BCC170AEQ35036275-5E3917CE-2BA2-4D05-A7BE-341EDF88CAB3Q35087817-C41F7F4B-4B92-43EA-9511-1F110B80CAC5Q35103890-9AE06124-2774-4586-B312-ED41D3EB9B73Q35579792-525D5CBD-A002-4FED-8A38-B23541EA047DQ35622426-E60A5F64-1280-43B1-BF41-B2CECE71CD7EQ35629419-D68FDCB0-F570-4D2B-882A-742DBFF570FAQ35653077-26C83CCE-1F81-4BBA-BAD6-DA7FB5D71839Q35842812-35CC4CA1-71BD-4BD9-B27E-8099B2E58937Q35917526-A3EC5BF5-AF44-44EE-BFAF-4AA9EB14DE92Q36233134-618D769F-577D-4347-89FD-5C76268EA4CBQ36260719-43BBB79C-54FD-4CD4-AA4E-F2CECEEC1E38Q36402052-4603B09D-21B9-4DA0-8C90-727D9ABB273BQ36828937-632F1AFA-0938-4E63-AFBD-04A59DA59244Q37020902-026142B9-D50D-4858-A885-82D44C1D94E8Q37232576-E43F036E-7345-4405-A0D2-C0A748FAD018Q37338603-59BAAAD3-0CDA-4881-8708-33EFF9E68DDFQ37412670-4E5018C9-2F67-41AF-B6EE-AD76A4FF00B7Q37452611-9BC8DFF9-4354-442B-8753-6A9B87A17E92Q37626125-30705E25-E15D-4E50-A584-EA5548C89715Q37701398-A8FA5327-A425-4E00-9BAD-2AA193257324Q37723091-76A7A659-440B-44CD-9333-840E3F11C529Q37791921-2830335C-64B6-4006-97C9-8C2A01743157Q37852898-9E9CAC30-8A5D-46F7-B3D3-81F0B2E1463EQ39504604-8A625803-25A8-4170-9063-D4E6A3E32A70
P2860
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@ast
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@en
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@nl
type
label
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@ast
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@en
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@nl
prefLabel
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@ast
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@en
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@nl
P2093
P2860
P3181
P356
P1476
Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)
@en
P2093
Amos Baruch
Ben N G Giepmans
E Lucio Benedetti
Irene Dunia
Nalin M Kumar
Peter A Nielsen
Valery I Shestopalov
P2860
P304
P3181
P356
10.1091/MBC.E02-10-0637
P407
P577
2003-06-01T00:00:00Z