The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity
about
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damagep38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shockAcetylation of the RhoA GEF Net1A controls its subcellular localization and activity.The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.Novel phosphotyrosine targets of FGFR2IIIb signaling.The Aarskog-Scott syndrome protein Fgd1 regulates podosome formation and extracellular matrix remodeling in transforming growth factor β-stimulated aortic endothelial cells.Tissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective.The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signalsNuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription.Expression of polarity genes in human cancer.Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1.The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype.Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasis.Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module.Human papillomaviruses, cervical cancer and cell polarity.Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activityEpithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment.PDZ domains: the building blocks regulating tumorigenesis.The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins.Neuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor κB activation.mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions.Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis.The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation.Stress activated MAPKs and CRM1 regulate Net1A subcellular localization to control cell motility and invasion.Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus.Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.
P2860
Q24294754-D2814E1A-4FD2-4991-969A-7FFC95B93082Q24604835-CB4664B5-8D45-49A5-903C-17E58FC0B251Q27342486-A405DFC0-7D83-41A2-9963-00B381F86E30Q30010159-E6481DE6-5353-4B41-ACC0-C4812B3C24ABQ30376698-7D80FBC3-1D8E-407A-B72D-1C3B2DCD43A7Q30427158-D1A97E86-89EF-4FCD-8528-FBD297CE5092Q33817720-50BA1ABB-A129-4585-96D6-303AA70479B5Q33842285-12747F85-6504-4BC8-B481-9669B9229B27Q34001688-8A1E93AA-E0AD-44D3-BE31-47C95D3EA249Q35323930-903A2EF0-6F87-4931-A1EC-C8AD7C4F6ED5Q36978333-3A9AE7CF-BF7A-4FD0-A65A-7446190EE022Q37104863-8E5E31D2-BE3D-407E-87CA-11BD33C09D32Q37115975-4E19D225-BD51-4394-AFBA-B2F51852A4C6Q37131476-E2D457FC-2C0E-4644-A33C-C2407E2283FCQ37159528-6A74DEE0-603B-4243-9F6C-733FE7FFAE27Q37333588-0F169776-55C6-43FA-BADE-0CF6E97E1B0AQ37333627-465B8718-78F5-4236-A455-A5DDE612C05CQ37433342-439E657A-9109-4D44-8EEC-733EF3DC8FC1Q37866083-807E3D70-F64B-4176-BA3C-37B4234B19B1Q37939947-954359ED-924B-4A1A-9FF5-4E1E06FBCE03Q38030668-375B2FC9-3C44-4E6C-A940-7C9E6A470DC2Q38327642-26017F9D-90F9-4964-89FD-F81D9A193753Q38719886-52D0A950-4A2D-4D1C-B771-959063707A3BQ40607486-477B2787-F729-4D4A-9944-6C5D3853E161Q47073233-2CF01DE6-A9F6-461F-9320-8A81929D07DEQ48183688-BD28BFEA-95A8-4AB3-8A87-4FEE78807FB5Q51839430-37AB5439-635A-477A-A25C-D6E10C9AD5CEQ52617207-689C3D8B-9DB7-457B-ADA8-25BDD7803965
P2860
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@ast
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@en
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@nl
type
label
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@ast
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@en
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@nl
prefLabel
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@ast
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@en
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@nl
P2093
P2860
P356
P1476
The nuclear RhoA exchange fact ...... heir tumor suppressor activity
@en
P2093
Adi D Dubash
Heather S Carr
Jeffrey A Frost
Keith Burridge
Lisa Sharek
Rafael García-Mata
P2860
P304
P356
10.1128/MCB.00157-07
P407
P577
2007-12-01T00:00:00Z