Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins - Test2 - elhamkhani - TriplyDB

Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

http://www.wikidata.org/entity/Q24681882

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Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells BMI1: A Biomarker of Hematologic Malignancies Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection Effects of Sodium Butyrate Treatment on Histone Modifications and the Expression of Genes Related to Epigenetic Regulatory Mechanisms and Immune Response in European Sea Bass (Dicentrarchus Labrax) Fed a Plant-Based Diet c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells Su(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activation Expression of Bmi-1 and PAI-1 in esophageal squamous cell carcinoma High BMI1 mRNA expression in peripheral whole blood is associated with favorable prognosis in advanced non-small cell lung cancer patients Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells.BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts.Oncogenic role of the chromobox protein CBX7 in gastric cancer.Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma.The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma.Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster.βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications.MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescence Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization.Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer.Bmi-1: At the crossroads of physiological and pathological biology.Bmi-1 expression modulates non-small cell lung cancer progression.Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling.A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway.Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence Antitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer.

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Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

http://www.wikidata.org/entity/Q24681882

description

2007 nî lūn-bûn

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2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins

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Molecular Biology of the Cell

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Goberdhan P Dimri

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Sonal Datta

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Wei-Jian Guo

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P2860

Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif

mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity

Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

Stem cells and ageing. The potential of stem cells to overcome age-related deteriorations of the body in regenerative medicine.

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

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