Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
about
Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathwaySeveral distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusMolecular genetic analysis of Suppressor 2 of zeste identifies key functional domainsBMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repressionMel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cellsBMI1: A Biomarker of Hematologic MalignanciesPolycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic ImplicationsThe variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesisEpithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connectionEffects of Sodium Butyrate Treatment on Histone Modifications and the Expression of Genes Related to Epigenetic Regulatory Mechanisms and Immune Response in European Sea Bass (Dicentrarchus Labrax) Fed a Plant-Based Dietc-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cellsSu(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activationExpression of Bmi-1 and PAI-1 in esophageal squamous cell carcinomaHigh BMI1 mRNA expression in peripheral whole blood is associated with favorable prognosis in advanced non-small cell lung cancer patientsDietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells.BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancerDeletion analysis of BMI1 oncoprotein identifies its negative regulatory domainmicroRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts.Oncogenic role of the chromobox protein CBX7 in gastric cancer.Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma.The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma.Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancerc-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster.βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications.MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescenceEhrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization.Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer.Bmi-1: At the crossroads of physiological and pathological biology.Bmi-1 expression modulates non-small cell lung cancer progression.Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling.A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway.Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrenceAntitumor activity and inhibitory effects on cancer stem cell-like properties of Adeno-associated virus (AAV) -mediated Bmi-1 interference driven by Bmi-1 promoter for gastric cancer.
P2860
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P2860
Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@ast
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@en
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@nl
type
label
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@ast
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@en
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@nl
prefLabel
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@ast
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@en
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@nl
P2093
P2860
P3181
P356
P1476
Mel-18, a polycomb group prote ...... f Bmi-1 and c-Myc oncoproteins
@en
P2093
Goberdhan P Dimri
Sonal Datta
Wei-Jian Guo
P2860
P304
P3181
P356
10.1091/MBC.E06-05-0447
P407
P50
P577
2007-02-01T00:00:00Z