Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
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Local amplification of glucocorticoids in the aging brain and impaired spatial memoryLong-Term Potentiation and MemoryGenetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.Neural Protein Synthesis during Aging: Effects on Plasticity and MemoryMetaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic taggingElectrophysiologic and behavioral effects of perinatal and acute exposure of rats to lead and polychlorinated biphenyls.NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian BrainFK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Age-related changes in behavior in C57BL/6J mice from young adulthood to middle ageA Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure.Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changeSystemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in miceMolecular mechanism for age-related memory loss: the histone-binding protein RbAp48Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memoryRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5A novel neurotrophic drug for cognitive enhancement and Alzheimer's diseaseA biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the ratDifferential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organsDopaminergic modulation of the persistence of one-trial hippocampus-dependent memoryIncreased axonal bouton dynamics in the aging mouse cortexCognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3).Aging in the cerebellum and hippocampus and associated behaviors over the adult life span of CB6F1 miceEffects of aging and sensory loss on glial cells in mouse visual and auditory cortices.Age sensitivity of behavioral tests and brain substrates of normal aging in mice.Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility.Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex.Thyroid hormone signaling and adult neurogenesis in mammalsCaloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis.Reinforcement of rat hippocampal LTP by holeboard trainingN-methyl-D-aspartate-stimulated ERK1/2 signaling and the transcriptional up-regulation of plasticity-related genes are developmentally regulated following in vitro neuronal maturation.The past, the future and the biology of memory storage.An epigenetic hypothesis of aging-related cognitive dysfunctionLearning and aging related changes in intrinsic neuronal excitabilityAge-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1Calcineurin links Ca2+ dysregulation with brain agingNonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training.Neural plasticity in the ageing brain.Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.Brief novelty exposure facilitates dentate gyrus LTP in aged rats
P2860
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P2860
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Age-related defects in spatial ...... nce the cAMP signaling pathway
@ast
Age-related defects in spatial ...... nce the cAMP signaling pathway
@en
Age-related defects in spatial ...... nce the cAMP signaling pathway
@nl
type
label
Age-related defects in spatial ...... nce the cAMP signaling pathway
@ast
Age-related defects in spatial ...... nce the cAMP signaling pathway
@en
Age-related defects in spatial ...... nce the cAMP signaling pathway
@nl
prefLabel
Age-related defects in spatial ...... nce the cAMP signaling pathway
@ast
Age-related defects in spatial ...... nce the cAMP signaling pathway
@en
Age-related defects in spatial ...... nce the cAMP signaling pathway
@nl
P2093
P2860
P3181
P356
P1476
Age-related defects in spatial ...... nce the cAMP signaling pathway
@en
P2093
E R Kandel
R D Hawkins
P2860
P304
P3181
P356
10.1073/PNAS.96.9.5280
P407
P577
1999-04-27T00:00:00Z