Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway - Test2 - elhamkhani - TriplyDB

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway

http://www.wikidata.org/entity/Q24684042

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Local amplification of glucocorticoids in the aging brain and impaired spatial memory Long-Term Potentiation and Memory Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.Neural Protein Synthesis during Aging: Effects on Plasticity and Memory Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging Electrophysiologic and behavioral effects of perinatal and acute exposure of rats to lead and polychlorinated biphenyls.NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure.Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48 Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5 A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory Increased axonal bouton dynamics in the aging mouse cortex Cognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3).Aging in the cerebellum and hippocampus and associated behaviors over the adult life span of CB6F1 mice Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices.Age sensitivity of behavioral tests and brain substrates of normal aging in mice.Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility.Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex.Thyroid hormone signaling and adult neurogenesis in mammals Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis.Reinforcement of rat hippocampal LTP by holeboard training N-methyl-D-aspartate-stimulated ERK1/2 signaling and the transcriptional up-regulation of plasticity-related genes are developmentally regulated following in vitro neuronal maturation.The past, the future and the biology of memory storage.An epigenetic hypothesis of aging-related cognitive dysfunction Learning and aging related changes in intrinsic neuronal excitability Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1 Calcineurin links Ca2+ dysregulation with brain aging Nonpharmacological amelioration of age-related learning deficits: the impact of hippocampal theta-triggered training.Neural plasticity in the ageing brain.Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.Brief novelty exposure facilitates dentate gyrus LTP in aged rats

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P2860

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway

http://www.wikidata.org/entity/Q24684042

description

1999 nî lūn-bûn

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1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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1999 թվականի ապրիլին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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Age-related defects in spatial ...... nce the cAMP signaling pathway

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Age-related defects in spatial ...... nce the cAMP signaling pathway

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Proceedings of the National Academy of Sciences of the United States of America

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Age-related defects in spatial ...... nce the cAMP signaling pathway

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E R Kandel

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H Son

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I Mansuy

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P2860

Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging.

Long-lasting forms of synaptic potentiation in the mammalian hippocampus.

Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro.

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.

Requirement of a critical period of transcription for induction of a late phase of LTP.

D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.

Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

Individual differences in the cognitive and neurobiological consequences of normal aging.

Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats.

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3860576

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10.1073/PNAS.96.9.5280

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9

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13078881

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10220457

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21855

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