Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
about
Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysisUnprocessed viral DNA could be the primary target of the HIV-1 integrase inhibitor raltegravirThe intrinsic mechanics of B-DNA in solution characterized by NMRSequence-dependent gating of an ion channel by DNA hairpin molecules.A targeted DNA substrate mechanism for the inhibition of HIV-1 integrase by inhibitors with antiretroviral activity.Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.HIV-1 Integrase-DNA Recognition Mechanisms.Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA.Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix.Structural and dynamic characterization of the upper part of the HIV-1 cTAR DNA hairpinVirtual screening for natural product inhibitors of HIV-1 integrase.Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop.Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
P2860
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P2860
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@ast
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@en
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@nl
type
label
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@ast
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@en
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@nl
prefLabel
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@ast
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@en
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@nl
P2093
P2860
P3181
P356
P1476
Pre-organized structure of viral DNA at the binding-processing site of HIV-1 integrase
@en
P2093
Ilham Cherrak
Jean-Guillaume Renisio
Olivier Mauffret
Saïd El Antri
Serge Fermandjian
Sylvain Cosquer
P2860
P304
P3181
P356
10.1093/NAR/GKI346
P407
P577
2005-04-06T00:00:00Z