Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution - Test2 - elhamkhani - TriplyDB

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

http://www.wikidata.org/entity/Q26269828

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Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles SNARE zippering PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strength A protocol for the refinement of NMR structures using simultaneously pseudocontact shift restraints from multiple lanthanide ions.Three steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex.Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan.Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.Functional synergy between the Munc13 C-terminal C1 and C2 domains.Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity N-terminal domain of complexin independently activates calcium-triggered fusion.Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.Structural characterization of the Rabphilin-3A-SNAP25 interaction.Sequence-specific assignment of methyl groups from the neuronal SNARE complex using lanthanide-induced pseudocontact shifts Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.Chaperoning SNARE assembly and disassembly The Structure of the Synaptic Vesicle-Plasma Membrane Interface Constrains SNARE Models of Rapid, Synchronous Exocytosis at Nerve Terminals.C2-domain containing calcium sensors in neuroendocrine secretion.A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.Morphologies of synaptic protein membrane fusion interfaces.A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion.A cascade of multiple proteins and lipids catalyzes membrane fusion.Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I How does the stimulus define exocytosis in adrenal chromaffin cells?The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment.Long-range paramagnetic NMR data can provide a closer look on metal coordination in metalloproteins.Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds.Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion.A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells.Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.Mechanism of neurotransmitter release coming into focus

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

http://www.wikidata.org/entity/Q26269828

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2015 nî lūn-bûn

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2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2015 թվականի հուլիսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1–SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

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Nature Structural & Molecular Biology

P1476

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

@en

P2093

Alexandre M J J Bonvin

http://www.w3.org/2001/XMLSchema#string

Alpay B Seven

http://www.w3.org/2001/XMLSchema#string

Amy Zhou

http://www.w3.org/2001/XMLSchema#string

Andrea Cavalli

http://www.w3.org/2001/XMLSchema#string

Bim Graham

http://www.w3.org/2001/XMLSchema#string

Eric A Prinslow

http://www.w3.org/2001/XMLSchema#string

James D Swarbrick

http://www.w3.org/2001/XMLSchema#string

Junjie Xu

http://www.w3.org/2001/XMLSchema#string

Kyle D Brewer

http://www.w3.org/2001/XMLSchema#string

Nicholas Barlow

http://www.w3.org/2001/XMLSchema#string

P2860

Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

Complexin controls the force transfer from SNARE complexes to membranes in fusion

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

Three-dimensional structure of the complexin/SNARE complex

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555-64

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scholarly article

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1437552

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10.1038/NSMB.3035

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P433

7

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22

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Michele Vendruscolo

Diana R. Tomchick

Carlo Camilloni

Daniel Häussinger

Thomas C. Südhof

P577

2015-07-01T00:00:00Z

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277601833

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1052784931

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26030874

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structural biology

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4496268

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