Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes - Test2 - elhamkhani - TriplyDB

Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes

Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes

http://www.wikidata.org/entity/Q26269851

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Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone Complexins: small but capable Differences in human cortical gene expression match the temporal properties of large-scale functional networks.Re-examining how complexin inhibits neurotransmitter release.Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins Membrane curvature sensing by the C-terminal domain of complexin.Functional roles of complexin in neurotransmitter release at ribbon synapses of mouse retinal bipolar neurons Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Re-visiting the trans insertion model for complexin clamping.Molecular underpinnings of synaptic vesicle pool heterogeneity.Interneuron Transcriptional Dysregulation Causes Frequency-Dependent Alterations in the Balance of Inhibition and Excitation in Hippocampus.Evolutionary conservation of complexins: from choanoflagellates to mice.Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex N-terminal domain of complexin independently activates calcium-triggered fusion.Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery.C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission Complexin splits the membrane-proximal region of a single SNAREpin.Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency.The molecular machinery of neurotransmitter release (Nobel lecture).The proteins of exocytosis: lessons from the sperm model.Molecular mechanisms governing Ca(2+) regulation of evoked and spontaneous release.Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Calcium dependence of spontaneous neurotransmitter release.KV 10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse.Reconstitution of calcium-mediated exocytosis of dense-core vesicles.Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.Targeting synaptic pathology with a novel affinity mass spectrometry approach.Activity-Dependence of Synaptic Vesicle Dynamics.Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity.Spontaneous neurotransmission: A form of neural communication comes of age.Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways.Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus.Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction.Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis.Mechanism of neurotransmitter release coming into focus

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Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes

http://www.wikidata.org/entity/Q26269851

description

2013 nî lūn-bûn

@nan

2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Deconstructing complexin funct ...... ckout and knockdown phenotypes

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

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type

label

Deconstructing complexin funct ...... ckout and knockdown phenotypes

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

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prefLabel

Deconstructing complexin funct ...... ckout and knockdown phenotypes

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

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PNAS.1321367110

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Proceedings of the National Academy of Sciences of the United States of America

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Deconstructing complexin funct ...... ckout and knockdown phenotypes

@en

P2093

Peng Cao

http://www.w3.org/2001/XMLSchema#string

Xiaofei Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Complexins: cytosolic proteins that regulate SNAP receptor function

Membrane fusion: grappling with SNARE and SM proteins

Neurotransmitter release: the last millisecond in the life of a synaptic vesicle

C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis

Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins

Postsynaptic complexin controls AMPA receptor exocytosis during LTP

Complexin controls the force transfer from SNARE complexes to membranes in fusion

Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10

Three-dimensional structure of the complexin/SNARE complex

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20777-82

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scholarly article

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1097533

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10.1073/PNAS.1321367110

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51

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110

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Thomas C. Südhof

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2013-12-17T00:00:00Z

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24297916

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