RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
about
mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle dockingRIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapseSynaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic VesiclesThe active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neuronsNeurotransmitter release: the last millisecond in the life of a synaptic vesicleThe presynaptic active zoneRIM genes differentially contribute to organizing presynaptic release sitesNeurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortexRab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learningRIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active ZoneRole of Bassoon and Piccolo in Assembly and Molecular Organization of the Active ZoneThe Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic PotentialMolecular mechanisms driving homeostatic plasticity of neurotransmitter releaseSynaptic vesicle recycling: steps and principlesThe dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteinsSustaining rapid vesicular release at active zones: potential roles for vesicle tetheringDistinct initial SNARE configurations underlying the diversity of exocytosisCell biology in neuroscience: the interplay between Hebbian and homeostatic synaptic plasticityRab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zonesProtein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosisComplexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activityHair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tetheringHeterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming CaV1.3 Ca2+ Channel Subunit and Promote Its Membrane Expression.RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.Are unreliable release mechanisms conserved from NMJ to CNS?Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses.A pink mouse reports the switch from red to green fluorescence upon Cre-mediated recombinationIndependent regulation of basal neurotransmitter release efficacy by variable Ca²+ influx and bouton size at small central synapses.Gene delivery in mouse auditory brainstem and hindbrain using in utero electroporation.Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.The immediately releasable pool of mouse chromaffin cell vesicles is coupled to P/Q-type calcium channels via the synaptic protein interaction site.Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release.NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development.Studying synaptic efficiency by post-hoc immunolabelling.
P2860
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P2860
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@ast
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@en
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@nl
type
label
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@ast
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@en
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@nl
prefLabel
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@ast
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@en
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@nl
P2860
P3181
P1433
P1476
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
@en
P2093
Pascal S Kaeser
Ralf Schneggenburger
P2860
P304
P3181
P356
10.1016/J.NEURON.2010.12.014
P407
P577
2011-01-27T00:00:00Z