Mechanisms of granulin deficiency: lessons from cellular and animal models
about
Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersGranulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathologyProgranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression.Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer.Frontotemporal Dementia and Psychiatric Illness: Emerging Clinical and Biological Links in Gene Carriers.Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.Innate immune activation in neurodegenerative disease.Microarray gene and miRNA expression studies: looking for new therapeutic targets for frontotemporal lobar degeneration.Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging.Genetics of FTLD: overview and what else we can expect from genetic studies.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Looking for Neuroimaging Markers in Frontotemporal Lobar Degeneration Clinical Trials: A Multi-Voxel Pattern Analysis Study in Granulin Disease.Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Molecular Genetics of Neurodegenerative Dementias.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.The Genetics of Monogenic Frontotemporal Dementia.Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress.Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.
P2860
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P2860
Mechanisms of granulin deficiency: lessons from cellular and animal models
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2013 nî lūn-bûn
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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Mechanisms of granulin deficiency: lessons from cellular and animal models
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Mechanisms of granulin deficiency: lessons from cellular and animal models
@en
Mechanisms of granulin deficiency: lessons from cellular and animal models
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type
label
Mechanisms of granulin deficiency: lessons from cellular and animal models
@ast
Mechanisms of granulin deficiency: lessons from cellular and animal models
@en
Mechanisms of granulin deficiency: lessons from cellular and animal models
@nl
prefLabel
Mechanisms of granulin deficiency: lessons from cellular and animal models
@ast
Mechanisms of granulin deficiency: lessons from cellular and animal models
@en
Mechanisms of granulin deficiency: lessons from cellular and animal models
@nl
P2860
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P1476
Mechanisms of granulin deficiency: lessons from cellular and animal models
@en
P2860
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P356
10.1007/S12035-012-8380-8
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2013-02-01T00:00:00Z
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P6179
1022313443