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Synthetic biology in mammalian cells: next generation research tools and therapeutics

Synthetic biology in mammalian cells: next generation research tools and therapeutics

http://www.wikidata.org/entity/Q26995293

about

Control theory meets synthetic biology Synthetic biology for pharmaceutical drug discovery Systems and synthetic biology approaches to alter plant cell walls and reduce biomass recalcitrance Nanobodies and recombinant binders in cell biology Multidisciplinary approach to genomics research in Africa: the AfriCRAN model Developments in the tools and methodologies of synthetic biology A Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live Cells CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.Molecular Imaging in Synthetic Biology, and Synthetic Biology in Molecular Imaging.Synthetic and systems biology for microbial production of commodity chemicals.Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.A designer cell-based histamine-specific human allergy profiler.Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions A simplified and versatile system for the simultaneous expression of multiple siRNAs in mammalian cells using Gibson DNA Assembly Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ Synthetic biology for therapeutic applications.Unique nucleotide sequence-guided assembly of repetitive DNA parts for synthetic biology applications.Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases Synthetic feedback control using an RNAi-based gene-regulatory device.Development of New Modular Genetic Tools for Engineering the Halophilic Archaeon Halobacterium salinarum Cosmetics-triggered percutaneous remote control of transgene expression in mice.A fungicide-responsive kinase as a tool for synthetic cell fate regulation.Synthetic biology: insights into biological computation.Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.Discriminating direct and indirect connectivities in biological networks.Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division.Molecular circuits for dynamic noise filtering.A dual molecular analogue tuner for dissecting protein function in mammalian cells Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer.Cellular heterogeneity mediates inherent sensitivity-specificity tradeoff in cancer targeting by synthetic circuits.Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs.Synthetic biology devices and circuits for RNA-based 'smart vaccines': a propositional review.Mammalian synthetic biology: emerging medical applications.The use of lineage tracing to study kidney injury and regeneration.Non-hormonal targets underlying endometriosis: A focus on molecular mechanisms.Mammalian designer cells: Engineering principles and biomedical applications.Promise and peril in nanomedicine: the challenges and needs for integrated systems biology approaches to define health risk.Tracking the emergence of synthetic biology Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.

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Synthetic biology in mammalian cells: next generation research tools and therapeutics

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2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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Synthetic biology in mammalian cells: next generation research tools and therapeutics

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Nature Reviews Molecular Cell Biology

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Synthetic biology in mammalian cells: next generation research tools and therapeutics

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Abhishek Garg

http://www.w3.org/2001/XMLSchema#string

Florian Lienert

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Jason J. Lohmueller

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

RNA-guided human genome engineering via Cas9

Targeting DNA double-strand breaks with TAL effector nucleases

Multiplex genome engineering using CRISPR/Cas systems

A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

Virus attenuation by genome-scale changes in codon pair bias

Higher-order cellular information processing with synthetic RNA devices

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

The genetic design of signaling cascades to record receptor activation

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10.1038/NRM3738

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24434884

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synthetic biology

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4032074

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